Molecular carrier for molecular detection

A molecular detection and molecular technology, which is used in laboratory containers, measuring devices, analytical materials, etc., can solve the problems of sample structure damage and cumbersome detection methods, and achieve the effect of improving the enhancement factor and enhancing Raman scattering.

Active Publication Date: 2019-03-15
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, the process of extracting samples may cause damage to the sample structure, and the process of extracting samples also makes the detection method cumbersome

Method used

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  • Molecular carrier for molecular detection
  • Molecular carrier for molecular detection
  • Molecular carrier for molecular detection

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Embodiment Construction

[0031] The present invention will be further described in detail below in conjunction with specific embodiments and accompanying drawings.

[0032] Please also refer to Figure 1 to Figure 2 , the first embodiment of the present invention provides a molecular carrier 10 for molecular detection, the molecular carrier 10 includes a substrate 11 , an intermediate layer 12 and a metal layer 13 . Specifically, the intermediate layer 12 is disposed on the surface of the substrate 11 , and the metal layer 13 is disposed on the surface of the intermediate layer 12 . The intermediate layer 12 includes a substrate 121 and a plurality of patterned protrusions 122 disposed on the substrate 121 , and the patterned protrusions 122 are disposed on a surface of the substrate 121 away from the base 11 . The patterned protrusion 122 may include a plurality of protruding lines intersecting to form a network structure, thereby defining a plurality of holes 124 . The intersections of the plurali...

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Abstract

The invention relates to a molecular carrier for molecular detection. The molecular carrier comprises a base, an intermediate layer and a metal layer, wherein the intermediate layer is arranged on thesurface o the base; the metal layer is arranged on the surface, far away from the base, of the intermediate layer; the base is a flexible substrate; the intermediate layer comprises a substrate and aplurality of patterned bumps arranged on the substrate; and the metal layer is arranged on the surfaces of the patterned bumps. The molecular carrier further comprises a carbon nanotube composite material which is arranged between the top surfaces of the patterned bumps and the metal layer.

Description

technical field [0001] The invention relates to a molecular carrier for molecular detection, a preparation method thereof and a method for detecting molecules using the carrier. Background technique [0002] Single Molecule Detection (SMD) technology is an ultra-sensitive detection technology that can detect a single molecule and is used in chemical analysis, DNA sequencing, nanomaterial analysis, medical diagnosis, molecular dynamics mechanism, food safety and other fields. Wide range of applications. Compared with traditional analysis methods, single-molecule detection method studies the individual behavior of the system in the non-equilibrium state, or the fluctuation behavior in the equilibrium state, so it is especially suitable for the study of chemical and biochemical reaction kinetics, biomolecular interactions, structure and Functional information, early diagnosis of major diseases, pathological research, and high-throughput drug screening, etc. [0003] At presen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658B01L3/5085B01L2300/06B01L2300/0829B01L2300/12G01N2021/651
Inventor 王营城金元浩李群庆范守善
Owner TSINGHUA UNIV
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