Application of compound FC-99 in preparing drug for preventing or treating acute hepatic failure

Abstract

The invention discloses application of FC-99 shown as a formula (I) in preparing drug for preventing or treating acute hepatic failure, particularly relates to application of FC-99 in inducing expression of Let-7a (microRNA Let-7A) to inhibit occurrence and development of hepatic failure so as to prevent or treat the hepatic failure and belongs to the field of biomedicine. By building an acute hepatic failure mouse animal model induced by D-aminogalactose combined with lipopolysaccharide and intervening fulminant hepatic failure through FC-99, a result shows that FC-99 can obviously lower transaminase, inhibit inflammation factor release, reduce hepatic cell apoptosis and maintain liver microscopic structure stable and can remarkably lower death rate of mice with acute hepatic failure; bioinformatic analysis and molecular biological detection find that FC-99 is realized by inducing high expression of Let-7a and inhibiting gene expression of IL-6, IRF4, CD86 and SOCS1 in a targeted manner. Therefore, research results show that the compound FC-99 can be applied in preparing drug for preventing or treating acute hepatic failure. In the above application, dosage range for injection andoral administration is 0.01-1000mg per day, and the range can be deviated according to illness degree or dosage form difference.

Description

technical field [0001] The invention relates to the prevention or treatment of liver failure by inhibiting the occurrence and development of liver failure by FC-99; specifically, the prevention or treatment of liver failure by FC-99 inducing the expression of Let-7a. technical background [0002] Acute liver failure (Acute liver failure, abbreviated as "ALF") is a type of severe liver damage caused by a variety of factors. A large number of liver cells die in a short period of time, which in turn leads to the synthesis, detoxification, excretion and biotransformation of the liver itself. A critical clinical syndrome with severe disorders; its etiology is complex, the disease develops rapidly, and the fatality rate is as high as about 50%, which seriously threatens the life safety of patients (Mark J.W.McPhail.et al., 2015, doi: 10.1097 / MOG.0000000000000174). my country is a country with a large population in the world. Every year, hundreds of thousands of people suffer from ...

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Problems solved by technology

There are currently no reports on the application of FC-99 in the treatment of acute liver failure

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