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A self-emulsifying oral preparation of terpene pharmaceutical composition and its preparation method and application

A technology for oral preparations and compositions, which is applied in the field of self-emulsifying oral preparations and preparations of terpene pharmaceutical compositions, can solve problems such as unstable preparation quality, achieve the effects of reducing irritation, ensuring therapeutic effects, and avoiding nausea

Active Publication Date: 2021-06-29
BEIJING GRAND JOHAUM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the technical problem to be solved by the present invention is to overcome the defect that the preparation quality is not stable in the oral formulations of the pharmaceutical composition containing eucalyptol, limonene and α-pinene prepared by the existing method, thereby providing a terpene drug Composition Self-emulsifying oral formulation

Method used

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  • A self-emulsifying oral preparation of terpene pharmaceutical composition and its preparation method and application
  • A self-emulsifying oral preparation of terpene pharmaceutical composition and its preparation method and application
  • A self-emulsifying oral preparation of terpene pharmaceutical composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The preparation of embodiment 1 terpene pharmaceutical composition self-emulsifying soft capsule

[0060] The prescription for self-emulsifying liquid medicine is:

[0061]

[0062]

[0063] The preparation method is:

[0064] (1) Take eucalyptol, limonene, α-pinene and soybean oil in the prescription amount, stir at 15°C at a speed of 50rpm for 1 hour, mix well, and obtain an oil phase;

[0065] (2) Add the prescribed amount of Tween 80 and propylene glycol into the oil phase, stir for 1 hour at 15°C at a speed of 50 rpm, and mix well to form a uniform self-emulsifying liquid medicine;

[0066] (3) Weigh gelatin, glycerin, and water to prepare capsule skins in a weight ratio of 1:0.5:1.1;

[0067] (4) Put the self-emulsifying medicinal liquid obtained in step (2) and the capsule skin obtained in step (3) on a soft capsule machine for pressing in a conventional manner, and place them in a setting machine for finalization to make a self-emulsifying soft capsule o...

Embodiment 2

[0068] The preparation of embodiment 2 terpene pharmaceutical composition self-emulsifying soft capsules

[0069] The prescription for self-emulsifying liquid medicine is:

[0070]

[0071] The preparation method is:

[0072] (1) Take eucalyptol, limonene, α-pinene and medium-chain triglycerides in the prescription amount, stir at 30°C for 2 hours at a speed of 30 rpm, and mix well to obtain an oil phase;

[0073] (2) Add the prescribed amount of Labrasol and Transcutol into the oil phase, stir at 30°C for 2 hours at a speed of 30rpm, and mix well to form a uniform self-emulsifying liquid medicine;

[0074] (3) Weigh gelatin, glycerin and water to prepare capsule skin according to the weight ratio of 1:0.45:1.1;

[0075] (4) Put the self-emulsifying medicinal liquid obtained in step (2) and the capsule skin obtained in step (3) on a soft capsule machine for pressing in a conventional manner, and place them in a setting machine for finalization to make a self-emulsifying s...

Embodiment 3

[0076] The preparation of embodiment 3 terpene pharmaceutical composition self-emulsifying soft capsule

[0077] The prescription for self-emulsifying liquid medicine is:

[0078]

[0079] The preparation method is the same as in Example 2.

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Abstract

The invention relates to the technical field of pharmaceutical preparations, and discloses a self-emulsifying oral preparation of a terpene pharmaceutical composition, a preparation method, and an application thereof. The self-emulsifying oral preparation includes eucalyptol, limonene and α-pinene in a specific proportion The composition, oil, emulsifier, co-emulsifier, and the mutual cooperation between the components make the prepared terpene drug composition self-emulsifying liquid medicine stable and uniform in property, and improve the self-emulsifying oral preparation of the terpene drug composition. The quality stability ensures the therapeutic effect of the drug, and is suitable for large-scale clinical promotion and use.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, and relates to a self-emulsifying oral preparation of a terpene pharmaceutical composition, a preparation method and an application thereof. Background technique [0002] The pharmaceutical composition containing eucalyptol, limonene and α-pinene can be used for cough relieving, anti-inflammation, expectorant and promoting the discharge of contrast medium for patients with respiratory diseases, and as an atomized inhalation agent for improving the symptoms caused by rhinitis and sinusitis. Mucociliary clearance system functional damage, such as disclosed in the prior art a pharmaceutical composition fat emulsion injection containing eucalyptol, limonene and α-pinene and its preparation method, the composition of the injection consists of eucalyptus Olein 0.0128-0.032%, limonene 0.0084-0.0210%, α-pinene 0.0028-0.0070%, soybean oil for injection 10-30%, egg yolk lecithin for inj...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K47/44A61K47/24A61K47/14A61K31/35A61K31/015A61P11/00A61P11/02A61P31/06A61P31/10
CPCA61K47/14A61K47/24A61K47/44A61P11/00A61P11/02A61P31/06A61P31/10A61K9/0053A61K9/107A61K31/015A61K31/35A61K2300/00
Inventor 韩悦耿海明沈芳玲赵家欣胡昱代向东霍扬扬
Owner BEIJING GRAND JOHAUM PHARMA CO LTD
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