Nine-in-one antitumor externally applied medicine patch composition

A technology for external application of drug patches and compositions, applied in the directions of antineoplastic drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as unfavorable treatment of patients with dysphagia, patients requiring oral drugs, etc., to achieve prevention, recurrence and distant Metastasis, shortening of radiotherapy time, and reducing the effects of radiotherapy toxicity and side effects

Inactive Publication Date: 2019-03-29
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent 201410325193.8 discloses an anti-tumor traditional Chinese medicine preparation. The selected raw materials and their weight components are: 10-20 grams of Strychnis chinensis, 10-20 grams of Wulingzhi, 5-10 grams of Agrimony, 5-10 grams of nitrate, 5-10 grams of realgar, 8-12 grams of isatidis, 8-15 grams of southern star, 10-20 grams of seaweed, 8-12 grams of forsythia, 10-20 grams of cat's eye grass, 5-10 grams of pangolin , Bezoar 5-10 grams, and Cistanche deserticola 5-10 grams, which have the advantages of fast curative effect, high cure rate, safety and convenience when used for anti-tumor treatment, but patients need to take drugs orally in the treatment process, which is not conducive to the treatment of dysphagia symptoms patients; Chinese patent 201410792223.6 discloses a traditional Chinese medicine composition and its regulation of human immune function and anti-tumor application. Its formula is simple, the formula is unique, it is convenient to use, and there is no bitterness, but it needs to be taken orally by the patient during the treatment process, which is not conducive to the treatment of patients with dysphagia

Method used

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  • Nine-in-one antitumor externally applied medicine patch composition
  • Nine-in-one antitumor externally applied medicine patch composition
  • Nine-in-one antitumor externally applied medicine patch composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] In the nine-in-one anti-tumor external application patch composition described in this embodiment, the raw materials are composed by weight: 6 parts of leeches, 15 parts of turtle shells, 12 parts of heterophylla, 18 parts of willow bark, 12 parts of knotweed, 9 parts of musk 50 parts, 50 parts of Nuxe chinensis, 18 parts of crab shells, 15 parts of roasted rice shells, 20-30 mesh powdered external application pharmaceutical compositions made according to the traditional Chinese medicine combination and preparation process, which can achieve anti-inflammatory effects through acupoint application. tumor efficacy.

[0015] For the production of nuxe seeds involved in this embodiment, first remove impurities and hair with raw nuxe seeds, then mix and soak them with skimmed milk at a weight ratio of 1:5 for 24 hours, then filter and wash them with clean water, and then use raw nuxe seeds Qianzi: Soak the mature vinegar in vinegar for 6-9 hours according to the weight ratio ...

Embodiment 2

[0021] In this example, the external application patch composition prepared in Example 1 was applied to tumor patients in the Center of Integrated Traditional Chinese and Western Medicine of Qingdao University, and it was observed that the external application patch composition was applied to acupoints and treated once a day, with 20 days as a course of treatment. Generally, physical fitness is re-evaluated after each course of treatment, and comprehensive curative effect evaluation standards are adopted. With reference to the "Guiding Principles for Clinical Research of New Chinese Medicines" issued by the National Health and Family Planning Commission, the curative effect judgment standards are as follows:

[0022] Recovery: all clinical symptoms disappear, laboratory tests are normal, and no recurrence is found within six months after recovery; the transformation score of physical fitness assessment is <30 points, and the transformation score of peace constitution is ≥80 poin...

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Abstract

The invention belongs to the technical field of preparation of traditional Chinese medicine composition and relates to antitumor externally applied medicine patch composition prepared from Chinese herbal medicines as raw materials. The composition comprises the following raw materials: hirudo, carapax trionycis, radix pseudostellariae, willow bark, rhizoma polygoni cuspidati, moschus, prepared semen strychni, crab shell and fried rice shell, wherein for the prepared semen strychni, impurities and hair are removed from raw semen strychni, then the semen strychni is soaked with skim milk for 24h and soaked with vinegar for 6-9 h, finally, the semen strychni is heated with sand for processing, and the prepared semen strychni is obtained for standby application; the carapax trionycis is processed with vinegar for use; the crab shell is stirred with liquor for use; the willow bark is stirred with soft fire to be parched, and powder is prepared for use; the raw material powder or commercially available raw materials are mixed in proportion and processed to form composition powder, then an externally applied medicine patch is processed with a conventional preparation process for the externally applied medicine patch, and is used for resisting tumor growth; the externally applied medicine patch adapts to wide patient population, relieves pain of the patients, reduces toxic and side effects of radiotherapy and chemotherapy and has an enhancing function in improving impurity and living quality of the patients with malignant tumor.

Description

Technical field: [0001] The invention belongs to the technical field of preparation of traditional Chinese medicine compositions, and relates to an anti-tumor pharmaceutical composition using Chinese herbal medicines as raw materials, in particular to an anti-tumor external application medicinal patch composition using Chinese herbal medicines as raw materials, its preparation process and its use method . Background technique: [0002] Tumor is one of the common diseases that threaten human health, second only to cardiovascular and cerebrovascular diseases, and is recognized as one of the most difficult diseases in the medical field today, with a high incidence rate and great harm to human life and health. At present, the methods of clinical treatment of malignant tumors are usually surgery, radiotherapy and chemotherapy. While killing cancer cells, many normal cells of the human body are also eliminated, which brings great pain and psychological pressure to patients. Among...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/70A61P35/00A61K35/55A61K35/586A61K35/612A61K35/62
CPCA61K9/0004A61K9/7023A61K35/55A61K35/586A61K35/612A61K35/62A61K36/36A61K36/56A61K36/704A61K36/76A61K36/899A61P35/00A61K2300/00
Inventor 倪同上王宏韬胡瑞鹏葛科立王婷婷张皓刘春燕王惠青周永红郭云良
Owner QINGDAO UNIV
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