The invention discloses anti-rheumatism medicinal liquor and a preparation method thereof. The anti-rheumatism medicinal liquor is prepared from the following raw materials in parts by weight: 10-15 parts of cortex acanthopanacis, 8-12 parts of ephedra, 5-10 parts of safflower, 10-15 parts of water pepper roots, 12-18 parts of bushy knotweed leaves, 10-15 parts of gentiana macrophylla, 16-22 parts of divaricate saposhnikovia roots, 12-18 parts of poria, 15-20 parts of eucommia, 17-23 parts of solamum melongena, 5-10 parts of achyranthes bidentata, 10-15 parts of angelica pubescens, 9-14 parts of radix angelica dahurica, 13-19 parts of ligusticum wallichii, 15-20 parts of jasmine, 18-24 parts of pangolin, 10-15 parts of ventilago leiocarpa benth, 5-10 parts of willow barks, 12-18 parts of harpagophytum procumbens and 500-600 parts of liquor of 60 degrees. The medicinal liquor disclosed by the invention has the effects of expelling wind, removing cold, clearing away heat, removing dampness, dredging collaterals, promoting blood circulation to remove blood stasis, diminishing inflammation and stopping pains, improves body immunity, has an obvious analgesic effect on pains caused by rheumatism and rheumatoid, has an obvious curative effect on diseases such as anemofrigid-damp arthralgia and arthralgia, can achieve the effects of treating both symptoms and root causes and not having a relapse after curing, and has the characteristics of being short in course of treatment, free from toxic and side effects, completely reliable, convenient to take, wide in medicine resource, low in cost and the like.