Compound, and preparation method and application of compound
A compound and reaction technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as use restrictions, achieve improved stability, environmental protection costs, and high chemical stability Effect
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[0061] The embodiment of the present application also provides a preparation method of the compound. The preparation method of the compound mainly includes the following steps: reacting a dendrimer having an amino group at the end with glyoxal.
[0062] Further, dendrimers with amino groups at the end groups react with glyoxal, and one or more of the amino groups at the end groups react with glyoxal to obtain one or more Schiff base structures; make at least one of the dendrimers The terminal group is (H 3 C-CH=N-).
[0063] Due to the specificity of its structure and molecular structure, the dendrimers with one or more end groups having a Schiff base structure can fluoresce and have the characteristic of fluorescent color development.
[0064] In the preparation method of the compound provided in the examples of this application, ethylene glycol changes the amino terminal group to obtain a dendrimer with a Schiff base structure. The product obtained by this preparation metho...
Embodiment 1
[0092] This embodiment provides six compounds, which are mainly prepared through the following steps:
[0093] Dissolve 10 mg of polyamidoamine in 3 ml of aqueous solution, adjust the pH of the solution to 10, then add excess glyoxal dropwise, react in the dark and stir for 12 hours, and the solution turns reddish brown after the reaction. After the reaction, the solution was placed in dialysis bags with different molecular weight cut-offs, and dialyzed with 2L deionized water for 24 hours. The dialyzed solution is lyophilized into a powder with a lyophilizer for long-term storage.
[0094] In this embodiment, 6 kinds of polyamidoamines with different molecular weights and different numbers of amino groups are selected for preparation, and the products are named as F-G0, F-G1, F-G2, F-G3, F-G4, and F-G5 accordingly; Specifically, polyamidoamine with a molecular weight of 28826 and an amino group of 128 is G5. The molecular weight of the raw material polyamidoamine, the numbe...
Embodiment 2
[0100] The present embodiment provides three compounds, which are mainly prepared through the following steps:
[0101] Take 10 mg of branched polyethylene glycol amines with different molecular weights and dissolve them in 3 ml of aqueous solution, adjust the pH of the solution to 9.5, then add excess glyoxal dropwise, react in the dark and stir for 12 hours, and the solution turns reddish brown after the reaction. After the reaction, the solution was placed in a dialysis bag corresponding to the molecular weight cut-off, and dialyzed with 2L of deionized water for 24 hours to obtain the product.
[0102] The mass average molecular weights of the branched polyethylene glycol amines are 800, 15000 and 25000 respectively.
[0103] The compounds provided in this example can be used to make fluorescent agents, fluorescent dyes, fluorescent powders, cell imaging materials, fluorescent nanomaterials, fluorescent probes, fluorescent kits, fluorescent probes, drug carriers, etc.
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Abstract
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