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Composition for improving kidney dysfunction, black ginseng extract and preparation method and application thereof

A technology of renal function and composition, applied in the field of compositions for improving renal insufficiency, to achieve the effects of improving renal function and chronic renal insufficiency

Inactive Publication Date: 2019-05-24
YANBIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is a lack of a black ginseng extract that can effectively improve renal insufficiency and its preparation method

Method used

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  • Composition for improving kidney dysfunction, black ginseng extract and preparation method and application thereof
  • Composition for improving kidney dysfunction, black ginseng extract and preparation method and application thereof
  • Composition for improving kidney dysfunction, black ginseng extract and preparation method and application thereof

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preparation example Construction

[0027] The present invention also provides a preparation method of the black ginseng extract described in the above scheme, the steps are as follows:

[0028] 1) mixing black ginseng powder and ethanol aqueous solution, performing ultrasonic extraction, and filtering to obtain a filtrate;

[0029] 2) Concentrating and drying the filtrate in step 1) to obtain black ginseng extract.

[0030] In the present invention, firstly, black ginseng powder and ethanol aqueous solution are mixed, ultrasonically extracted, and filtered to obtain a filtrate.

[0031] In the present invention, the black ginseng powder is preferably Yanbian black ginseng powder, more preferably Yanbian black ginseng powder purchased from Yanbian Black Ginseng Health Food Co., Ltd.; the particle size of the black ginseng powder is preferably 30-60 mesh , more preferably 40 to 50 meshes; the volume percentage of ethanol in the ethanol aqueous solution is preferably 55% to 75%, more preferably 60% to 70%, most p...

Embodiment 1

[0039] Embodiment 1 A kind of extraction method of the black ginseng extract that improves renal function

[0040] Mix 2 g of Yanbian black ginseng powder (purchased from Yanbian Black Ginseng Health Food Co., Ltd., sieved through a 30-mesh sieve) with 30 mL of ethanol water solution with a volume fraction of 55%, and extract twice by ultrasonic (200W, 80kHz) at 20°C. Filtrate for 50 minutes each time, concentrate the filtrate under reduced pressure to a solid-liquid ratio of 1:1, pre-freeze the concentrated solution at -20°C for 4 hours, and vacuum freeze-dry at -40°C for 48 hours to obtain the black ginseng extract.

Embodiment 2

[0041] Embodiment 2 A kind of extraction method of the black ginseng extract that improves renal function

[0042] Mix 2 g of Yanbian black ginseng powder (purchased from Yanbian Black Ginseng Health Food Co., Ltd., sieved through a 50-mesh sieve) with 50 mL of ethanol water solution with a volume fraction of 75%, and extract it four times by ultrasonic (200W, 70kHz) at 30°C. Filter for 40 minutes each time, concentrate the filtrate under reduced pressure to a solid-liquid ratio of 1:1, pre-freeze the concentrated solution at -40°C for 6 hours, and vacuum freeze-dry at -50°C for 84 hours to obtain the black ginseng extract.

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Abstract

The invention provides a composition for improving kidney dysfunction and belongs to the technical field of ginseng deep-processing. The composition comprises, by weight, 2-6 parts of ginsenoside Rg2,1-5 parts of ginsenoside Rg5 and 1-3 parts of ginsenoside Rk1. The composition participates in slowing down the progress of chronic kidney interstitial fibrosis by inhibiting HK-2 phenotypic differentiation so as to improve chronic kidney dysfunction. It is verified that the composition can remarkably improve kidney functions of patients at 2-3 stages of chronic kidney dysfunction CKD.

Description

technical field [0001] The invention relates to the technical field of ginseng deep processing, in particular to a composition for improving renal insufficiency, a black ginseng extract, a preparation method and application thereof. Background technique [0002] Ginseng (Panaxgenseng C.A.Mey) is the dry root of Araliaceae plant ginseng, which is a famous nourishing medicine in ancient and modern times. Flat in nature, sweet in taste, slightly bitter, slightly warm. It is used for invigorating vital energy, promoting body fluid to quench thirst, calming the nerves and improving intelligence. [0003] Black ginseng is based on the principle of "nine steams and nine exposures", one of the traditional Chinese medicine production methods, and is processed through processes such as infiltration, cleaning, sorting, steaming, drying, and drying. During the steaming process of black ginseng, due to the nine-steaming and nine-drying process, there are slight changes in the compositi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K36/258A61P13/12A61K125/00
Inventor 郭建鹏陈林郑红英左阿龙李钟星
Owner YANBIAN UNIV
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