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A kind of preparation method and application of capsule dispersion

A technology of dispersion and capsule, applied in the field of preparation of capsule dispersion, can solve the problems of incomparable sunscreen effect and low content of sunscreen ingredients, and achieve the effects of overcoming greasy skin feeling, flexible particle size adjustment, and good encapsulation effect.

Active Publication Date: 2022-04-22
WANHUA CHEM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent application CN201410775011.7 wraps natural green pigment with hydrogel material and water-soluble film-forming material, the ratio is 4:1-8:1, and the content of sunscreen ingredients is low. The sunscreen effect of this natural green pigment cannot be compared with professional sunscreen agents

Method used

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  • A kind of preparation method and application of capsule dispersion
  • A kind of preparation method and application of capsule dispersion
  • A kind of preparation method and application of capsule dispersion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Embodiment 1 (this embodiment is comparative example)

[0080] Preparation of EC / OMC Sunscreen Capsule Dispersion:

[0081] Capsule wall material: EC—8g

[0082] Capsule core material: OMC—8g

[0083] Organic solvent: ethyl acetate—30g

[0084] Water: 35g

[0085] The capsule wall material and capsule core material are dissolved in an organic solvent to obtain an organic phase mixed liquid. Mix the organic phase mixture with water, and disperse for 10 minutes at a dispersion rate of 12000 rpm. The dispersed oil-in-water emulsion is homogenized 5 times under a homogeneous pressure of 5000 psi. The dispersion-homogenized emulsion is stirred at room temperature for 10 hours until organic The solvent is completely evaporated to obtain the final product EC / OMC sunscreen capsule dispersion.

[0086] The dispersion agglomerates during the evaporation of the organic solvent and deposits into visible lumps, which cannot be tested by dynamic light scattering.

Embodiment 2

[0087] The preparation of embodiment 2 EC / OMC sunscreen capsule dispersion

[0088] Capsule wall material: EC—8g

[0089] Capsule core material: OMC—8g

[0090] Organic solvent: ethyl acetate—30g

[0091] Surface stabilizer: Tween 80—1.6g

[0092] Water: 35g

[0093] The capsule wall material and the capsule core material are dissolved in an organic solvent to obtain an organic phase mixed liquid A, and the surface stabilizer is dissolved in water to obtain an aqueous phase mixed liquid B. Mix A and B and disperse for 10 minutes at a dispersion rate of 12000rpm. The dispersed emulsion is homogenized 5 times under a homogeneous pressure of 5000psi. The dispersed-homogenized emulsion is stirred at room temperature for 10h until the organic solvent is completely volatilized to obtain the final The product of EC / OMC sunscreen capsule dispersion.

[0094] The average particle diameter of the obtained EC / OMC sunscreen capsules is 514nm, the PdI is 0.19, the ζ-potential is -6mV,...

Embodiment 3

[0095] Example 3 Preparation of EC / OMC sunscreen nanocapsules

[0096] Capsule wall material: EC—8g

[0097] Capsule core material: OMC—8g

[0098] Organic solvent: ethyl acetate—30g

[0099] Surface stabilizer: Tween 80—0.8g, PVA—0.4g, SDS—0.08g

[0100] Water: 35g

[0101] The capsule wall material and the capsule core material are dissolved in an organic solvent to obtain an organic phase mixed liquid A, and the surface stabilizer is dissolved in water to obtain an aqueous phase mixed liquid B. Mix A and B and disperse for 10 minutes at a dispersion rate of 12000rpm. The dispersed emulsion is homogenized 5 times under a homogeneous pressure of 5000psi. The dispersed-homogenized emulsion is stirred at room temperature for 10h until the organic solvent is completely volatilized to obtain the final The product of EC / OMC sunscreen capsule dispersion.

[0102] The average particle diameter of the obtained EC / OMC sunscreen capsules is 372nm, the PdI is 0.11, the ζ-potential ...

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Abstract

The invention provides a preparation method of a capsule dispersion and its application. The preparation method of the capsule dispersion of the present invention comprises the following steps: dissolving a capsule wall material and a capsule core material in an organic solvent as an organic phase, adding a surface stabilizer It is dissolved in water as the water phase, the organic phase and the water phase are emulsified to form an oil-in-water emulsion, and the organic solvent in the emulsion is evaporated to obtain a dispersion in which capsules are dispersed. The preparation method of the capsule dispersion provided by the invention not only has a simple process, but also can produce a capsule dispersion with good dispersibility, has a high encapsulation rate for capsule core components, does not leave harmful substances to human body, and is safe and reliable.

Description

technical field [0001] The invention relates to a capsule dispersion, in particular to a preparation method of the capsule dispersion, and the method is applied to the preparation of capsules, capsule dispersions, sunscreen capsules, sunscreen capsule dispersions and the like. Background technique [0002] Capsules (or microcapsules) comprise a core and a wall surrounding the core. Capsules often have different uses according to the nature of the capsule core, mainly for the controlled release of active ingredients. At present, the commonly used method of encapsulation technology for encapsulating active ingredients is to encapsulate active ingredients in polymers by monomer synthesis, but this method has the disadvantage of low encapsulation rate, and the final particle dispersion is very likely to contain catalysts , monomers and their oligomers, which pose health risks to users. [0003] For products containing sunscreens, sunscreens are commonly used, which are directl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/85A61K8/81A61K8/73A61K8/49A61K8/11A61K8/37A61Q17/04
CPCA61K8/731A61K8/85A61K8/8152A61K8/8129A61K8/4993A61K8/11A61K8/375A61K8/37A61Q17/04A61K2800/56
Inventor 李保耀张川
Owner WANHUA CHEM GRP CO LTD