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A kind of oral ulcer spray and preparation method thereof

An oral ulcer and spray technology, which is applied in the field of oral ulcer spray and its preparation, can solve the problem of difficult recovery of local mucosa, and achieve good therapeutic effect.

Active Publication Date: 2021-07-30
广州赛琅生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no complete cure for recurrent oral ulcers clinically, and generally speaking, relatively large and deep oral ulcers (major aphthous ulcers) will form scars locally after healing. The scar will gradually become soft, absorbed, and smaller, but it is difficult for the local mucosa to return to its original state.

Method used

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  • A kind of oral ulcer spray and preparation method thereof
  • A kind of oral ulcer spray and preparation method thereof
  • A kind of oral ulcer spray and preparation method thereof

Examples

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preparation example Construction

[0038] In the present invention, the preparation method of the champa flower alcohol extract preferably comprises the following steps:

[0039] 1) mixing Zanba flower with the first ethanol solution, extracting for 1-2 hours, and obtaining the first filtrate and the first filter residue after filtering; the volume percentage of the first ethanol solution is 60-70%;

[0040] 2) The first filter residue obtained in the step 1) is mixed with the second ethanol solution and then extracted for 1-2 hours, and the second filtrate and the second filter residue are obtained after filtration; the volume percentage of the second ethanol solution is 55-50% 65%;

[0041] 3) The second filter residue obtained in the step 2) is mixed with the third ethanol solution and extracted for 1-2 hours, and the third filtrate and the third filter residue are obtained after filtering; the volume percentage of the third ethanol solution is 55-50% 65%;

[0042] 4) Mix the first filtrate obtained in the...

Embodiment 1

[0071] The preparation method of oral ulcer spray:

[0072] Step 1: Preparation of preservatives: Accurately weigh 15g of methyl p-hydroxybenzoate, add 250ml of 1,3-butanediol solution, stir until clear, fully dissolved, and stand for half an hour to observe whether there is precipitation of insoluble matter. get preservatives;

[0073] Step 2: Accurately weigh vitamin B according to the actual amount of prepared liquid 2 0.06g, add a little sodium hydroxide solution, after fully dissolving, accurately measure 16ml of champagne alcohol extract, add 1ml of deionized water;

[0074] Step 3: Take 0.08ml of preservative, mix it into the above solution, and stir to make the mixture even;

[0075] Step 4: Take 2ml of the stem cell extract, stir to make the mixture uniform, and finally adjust the pH value to 7.0 with sodium hydroxide or sodium citrate to obtain 20ml of oral ulcer spray.

[0076] The preparation method of Champa flower alcohol extract is as follows: take Champa fl...

Embodiment 2

[0082] The preparation method of oral ulcer spray:

[0083] Step 1: Preparation of preservatives: Accurately weigh 15g of methyl p-hydroxybenzoate, add 250ml of 1,3-butanediol solution, stir until clear, fully dissolved, and stand for half an hour to observe whether there is insoluble matter precipitated, get preservatives;

[0084] Step 2: Accurately weigh vitamin B according to the actual amount of prepared liquid 2 0.02g, add a little sodium hydroxide solution, after fully dissolving, accurately measure the champagne flower alcohol extract 14ml that embodiment 1 prepares, add deionized water 4ml;

[0085] Step 3: Take 0.08ml of preservative, mix it into the above solution, and stir to make the mixture even;

[0086]Step 4: Take 1ml of the stem cell extract prepared in Example 1, stir to make the mixture uniform, and finally adjust the pH value to 7.0 with sodium hydroxide or sodium citrate to obtain 20ml of oral ulcer spray.

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Abstract

The invention provides an oral ulcer spray and a preparation method thereof, belonging to the technical field of oral ulcer treatment, comprising the following components in parts by volume: 75-85 parts of chamomile alcohol extract, 5-15 parts of stem cell extract, 3-8 parts of deionized water, 2-6 parts of preservatives and vitamin B 2 0.1-0.5 parts; the concentration of exosome protein in the stem cell extract is 25-35 mg / mL; the pH value of the oral ulcer spray is 6.6-7.11. The oral ulcer spray provided by the invention has a good therapeutic effect, feels mild and comfortable when used, has no scar after being cured, and has a total effective rate of 97.22% for oral ulcer patients.

Description

technical field [0001] The invention relates to the technical field of treating oral ulcers, in particular to an oral ulcer spray and a preparation method thereof. Background technique [0002] Ulcers are more common on the tongue, lips, and gums. When oral ulcers attack, the pain is severe and the local burning pain is obvious. In severe cases, it will affect eating and speaking, and it may also cause halitosis and chronic pharyngitis. If it is not treated in time, it will cause great inconvenience to daily life. There are many inducing factors, such as local trauma, irritants, bacterial infections, endocrine imbalance, depression, mental stress, etc. can cause ulcers. [0003] Recurrent oral ulcers are roughly divided into three types: minor aphthous ulcers, major aphthous ulcers, and herpetiform ulcers. Minor aphthous ulcers are the most common and have a high recurrence rate. Clinically, the treatment of aphthous oral ulcers can be divided into: (1) symptomatic and sup...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/24A61K9/12A61P1/02A61K31/525A61K35/28
CPCA61K9/006A61K9/12A61K31/525A61K35/28A61K36/24A61K2236/333A61K2236/39A61P1/02A61K2300/00
Inventor 陈镇洲冯焯威刘兵钟健
Owner 广州赛琅生物技术有限公司
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