A microsphere of α-tocopherol and its preparation method

A technology of tocopherol and microspheres, which can be used in food forming, animal feed forming or processing, animal husbandry, etc. It can solve the problems that have not been reported yet, and achieve excellent chemical stability, low cost, and high bioavailability Effect

Active Publication Date: 2022-02-18
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been many literatures on the biological functions of betaine-rich, there is no relevant report on improving the stability or bioavailability of vitamin E.

Method used

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  • A microsphere of α-tocopherol and its preparation method
  • A microsphere of α-tocopherol and its preparation method
  • A microsphere of α-tocopherol and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1 (preparation of d-alpha-tocopherol microspheres)

[0047] Add d-α-tocopherol oil (22g, purity 98.7%) and betaine powder (11.5g) into methanol (250mL), heat to 25°C and stir to dissolve, cool rapidly, and after about 10 minutes (2.7°C ) precipitated a large amount of white precipitate, further cooled to -17 ° C, filtered, and dried the obtained solid powder to obtain 22.5 g of d-α-tocopherol microsphere powder with a yield of 67.2%.

[0048] Its XRPD pattern, DSC pattern, IR pattern, Raman pattern, and scanning electron microscope photos are shown in Figure 1-5 .

Embodiment 2

[0049] Embodiment 2 (preparation of d-alpha-tocopherol microspheres)

[0050] Add d-α-tocopherol oil (22g, with a purity of 95.3%) and betaine powder (5.8g) into ethanol (250mL), heat to 30°C and stir to dissolve, then cool rapidly, and after about 8 minutes (14°C ) precipitated a large amount of white precipitate, further cooled to -12.5 ° C, filtered, and dried the obtained solid powder to obtain 20.9 g of microsphere powder of d-α-tocopherol with a yield of 75.2%. Its scanning electron microscope pictures are as Image 6 shown.

Embodiment 3

[0051] Embodiment 3 (preparation of dl-alpha-tocopherol microspheres)

[0052] Add dl-α-tocopherol (83g, purity 91.4%) and betaine (31.5g) to ethanol (500mL), heat to 35°C and stir to dissolve, then cool rapidly, and a large amount of white precipitate will precipitate at about -12°C The product was further cooled to -18°C, filtered, and the obtained solid powder was dried to obtain 76.7 g of microsphere powder of dl-α-tocopherol, with a yield of 70%. Its scanning electron microscope pictures are as Figure 7 shown.

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Abstract

The present invention relates to a microsphere of α-tocopherol, its preparation method and use. The microspheres use betaine as a carrier, and are obtained by cooling and crystallization under the action of stirring or vortexing. The obtained microspheres have high tocopherol loading, good sphericity and fluidity, high melting point, and have excellent chemical stability and higher bioavailability. The microspheres can be used for preparing animal feed or human nutrition and health care products.

Description

technical field [0001] The invention relates to a microsphere of alpha-tocopherol and a preparation method thereof. Background technique [0002] Vitamin E is an important fat-soluble vitamin with a wide range of physiological functions in animals / humans. As an effective antioxidant and immunomodulator, it plays an important role in enhancing the immunity and antioxidant capacity of livestock and poultry, preventing infertility, improving the production performance of livestock and poultry, and improving the meat quality of livestock and poultry. Therefore, it is widely used in food processing, animal feed and human nutrition and health products. [0003] Vitamin E includes natural vitamin E and synthetic vitamin E, synthetic vitamin E is dl-α-tocopherol, natural tocopherol includes α, β, γ, δ-tocopherol and α, β, γ, δ-tocotrienol. Tocopherol itself is in the form of an oily liquid, sensitive to oxygen, and unstable when exposed to air, so it is generally derivatized into ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L33/15A23L29/00A23P10/30A23K20/174A23K20/105A23K40/30
CPCA23L33/15A23L29/045A23P10/30A23K20/174A23K20/105A23K40/30A23V2002/00
Inventor 梅雪锋朱冰清张奇陆鹂烨王建荣
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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