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Application of panax notoginseng total saponins combined with tanshinone IIA in preparation of drug for preventing colorectal cancer

A technology of Panax notoginseng saponins and colorectal cancer, applied in the field of traditional Chinese medicine, can solve the problems of clear adverse reactions, unapproved primary and secondary preventive drugs for colorectal cancer, etc., to promote tumor cell apoptosis and reduce cell survival rate , the effect of promoting apoptosis

Inactive Publication Date: 2019-09-06
曹文
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Problems solved by technology

[0005] Relevant studies have found that more than 85%-90% of colorectal cancers are evolved from colorectal adenomas, and adenomas are mainly caused by inflammation and alcohol stimulation. Colorectal adenomas are considered to be important cancers of colorectal cancer. For precancerous lesions, some people in the United States have recommended regular use of low-dose aspirin to prevent the occurrence of colorectal cancer and cardiovascular diseases, but aspirin has clear adverse reactions in the digestive tract, and it has not been approved as a primary or secondary preventive drug for colorectal cancer in my country

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  • Application of panax notoginseng total saponins combined with tanshinone IIA in preparation of drug for preventing colorectal cancer
  • Application of panax notoginseng total saponins combined with tanshinone IIA in preparation of drug for preventing colorectal cancer
  • Application of panax notoginseng total saponins combined with tanshinone IIA in preparation of drug for preventing colorectal cancer

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[0037] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.

[0038] 88 Balb / c male mice were randomly divided into 11 groups according to body weight, 8 in each group; they were AOM+DSS model control group, Panax notoginseng saponins+tanshinone ⅡA low dose group, notoginseng total saponins+tanshinone ⅡA Medium dose group, Panax notoginseng saponins+Tanshinone ⅡA high dose group, Panax notoginseng saponins low dose group, Panax notoginseng saponins medium dose group, Panax notoginseng saponins high dose group, Tanshinone ⅡA low dose group, Tanshinone ⅡA medium dose group , Tanshinone Ⅱ A high-dose group, blank control group. The first 10 groups were given intraperitoneal injection of AOM12.5mg / kg once, and the blank control group was injected with the same amount of 0.9% Nacl aqueous solution. The first 10 g...

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Abstract

The invention discloses application of panax notoginseng total saponins combined with tanshinone IIA in preparation of drug for preventing colorectal cancer, and relates to the technical field of traditional Chinese medicines. 900 mg of the panax notoginseng total saponins and 60 mg of the tanshinone IIA are used. According to the invention, the traditional Chinese medicine monomer panax notoginseng total saponins are combined with the tanshinone IIA to prevent inflammatory colorectal cancer in mice, and a COX-2 signal path is explored to be a key action mechanism, so that development of traditional Chinese medicines in the cause of tumor prevention is promoted, and a powerful basis is provided for preventive treatment of diseases of the traditional Chinese medicine.

Description

[0001] Technical field: [0002] The invention relates to the technical field of traditional Chinese medicine, in particular to the application of Panax notoginseng saponins combined with tanshinone IIA in the preparation of colorectal cancer prevention medicines. [0003] Background technique: [0004] Colorectal cancer is a common malignant tumor in my country, and the incidence of colorectal cancer has increased by 3-4% annually in the past 30 years. Globocan 2012 published by the International Agency for Research on Cancer (IARC) of the World Health Organization estimates that the standardized incidence rate of CRC in mainland China is 14.2 / 100,000, ranking 75th in the world, and the standardized case fatality rate is 7.4 / 100,000 , ranking 78th in the world. However, the morbidity and mortality of CRC in my country accounted for 18.6% and 20.1% of the total number of morbidity and death in the world respectively, both ranking first. According to the national cancer regist...

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Application Information

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IPC IPC(8): A61K36/258A61K31/58A61P35/00
CPCA61K31/58A61K36/258A61P35/00A61K2300/00
Inventor 曹文
Owner 曹文
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