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Myristoyl pentapeptide-17 with obvious promotion of eyelash growth and solid phase synthesis method thereof

A myristoyl pentapeptide, solid-phase synthesis technology, applied in the field of biomedicine, to achieve the effect of mild reaction conditions, high purity, and short synthesis cycle

Inactive Publication Date: 2019-09-06
南京迪维奥医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But about preparation of the present invention a kind of beauty wins the peptide that promotes eyelashes to obviously grow, there is no report yet
[0009] At present, there is a lack of a high-efficiency and high-purity myristoyl pentapeptide-17 that can significantly promote eyelash growth and its solid-phase synthesis method

Method used

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  • Myristoyl pentapeptide-17 with obvious promotion of eyelash growth and solid phase synthesis method thereof
  • Myristoyl pentapeptide-17 with obvious promotion of eyelash growth and solid phase synthesis method thereof
  • Myristoyl pentapeptide-17 with obvious promotion of eyelash growth and solid phase synthesis method thereof

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Effect test

Embodiment 1

[0052] Such as figure 1 with figure 2 As shown, a myristoyl pentapeptide-17 of the present invention that can significantly promote eyelash growth, the amino acid sequence of the myristoyl pentapeptide-17 that can significantly promote eyelash growth is shown in SEQ ID NO:1 amino acid sequence.

[0053] The solid-phase synthesis method of myristoyl pentapeptide-17 which obviously promotes eyelash growth according to the present invention comprises the following steps:

[0054] (1) connecting the first protected amino acid to the resin;

[0055] a1. In the polypeptide reactor with a sand core, add the resin after swelling and activation treatment in sequence, filter with suction, wash the resin, and dry it under reduced pressure; the protection method of solid-phase peptide synthesis is much simpler than that of liquid-phase peptide synthesis, so The above-mentioned protected amino acids are groups used for α-amino protection. In solid-phase peptide synthesis, there are usu...

Embodiment 2

[0079] The difference between Example 2 and Example 1 is that the solid-phase synthesis method of myristoyl pentapeptide-17 which significantly promotes eyelash growth according to the present invention comprises the following steps:

[0080] In step (1), the first protected amino acid is connected to the resin;

[0081] a1. In the polypeptide reactor with a sand core, sequentially add the resin after swelling and activation treatment, filter with suction, wash the resin, and dry it under reduced pressure; the protected amino acid is Moz (p-methoxybenzyloxycarbonyl).

[0082] The protection method of solid-phase peptide synthesis is much simpler than that of liquid-phase peptide synthesis. The protected amino acid is a group used for α-amino protection. In solid-phase peptide synthesis, there are usually Boc (tert-butoxycarbonyl), Moz ( p-methoxybenzyloxycarbonyl) and Fmoc (9-fluorenylmethyleneoxycarbonyl).

[0083] In the Fmoc (9-fluorenemethyleneoxycarbonyl) protection method...

Embodiment 3

[0104] The difference between Example 3 and Example 1 is that the present invention has a solid-phase synthesis method of myristoyl pentapeptide-17 that obviously promotes eyelash growth, comprising the following steps:

[0105] (1) connecting the first protected amino acid to the resin;

[0106] a1. In the polypeptide reactor with a sand core, sequentially add the resin after swelling and activation treatment, filter with suction, wash the resin, and dry it under reduced pressure; the protected amino acid is Fmoc (9-fluorenomethyleneoxycarbonyl).

[0107] The protection method of solid-phase peptide synthesis is much simpler than that of liquid-phase peptide synthesis. The protected amino acid is a group used for α-amino protection. In solid-phase peptide synthesis, there are usually Boc (tert-butoxycarbonyl), Moz ( p-methoxybenzyloxycarbonyl) and Fmoc (9-fluorenylmethyleneoxycarbonyl).

[0108] In the Fmoc (9-fluorenemethyleneoxycarbonyl) protection method, the protected am...

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Abstract

The invention discloses myristoyl pentapeptide-17 with obvious promotion of eyelash growth and a solid phase synthesis method thereof. The myristoyl pentapeptide-17 with obvious promotion of eyelash growth has an amino acid sequence shown in SEQ ID NO: 1. The crude peptide obtained by the method of the present invention has a high yield of greater than 60% and a high purity of greater than 96%. The problem existing in the prior art is better solved, the myristoyl pentapeptide-17 has the effect of obviously promoting hair growth, and the synthesized myristoyl pentapeptide-17 can be applied to the fields of food, pharmaceutical, cosmetics and the like.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a myristoyl pentapeptide-17 which can obviously promote the growth of eyelashes and a solid-phase synthesis method thereof. Background technique [0002] At present, the chemical synthesis of peptides is mainly divided into two methods: liquid-phase synthesis and solid-phase synthesis. In the past, peptide synthesis was carried out in solution, which was called liquid-phase synthesis. Nowadays, peptide synthesis mostly uses solid-phase synthesis. [0003] Hair is a special variant organ of epidermal differentiation with complex keratinized appendage structure. Hair grows from hair follicles and can be divided into two parts: hair shaft and hair root. Hair covered in this article includes eyelashes, eyebrows, and hair. [0004] With the rapid development of society and economy in today's world, people pay more and more attention to the eyelashes with aesthetic and protective ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06C07K1/06C07K1/04A61K8/64A61Q7/00G01N27/62G01N30/02
CPCC07K7/06A61K8/64A61Q7/00G01N33/6848G01N30/02
Inventor 李华周章勇许驰名王忠长朱海亮
Owner 南京迪维奥医药科技有限公司
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