Evaluation method for anti-allergen substance for cosmetics

A cosmetic and allergy-relieving technology, which is applied in the field of evaluation of allergy-relieving substances used in cosmetics, can solve the problems such as the inability to truly reflect the anti-allergic effect of allergen-relieving substances on sensitive skin, the duration of anti-allergic activity, and the high operator requirements.

Inactive Publication Date: 2019-10-11
SHANGHAI ZHONGYI DAILY CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current domestic research on sensitizing substances for cosmetics is still in its infancy, and the existing evaluation methods usually need to be completed in a specific environment, which has high requirements for operators, and there is often a gap between the experimental results and the results of human use. Differences, unable to truly reflect the anti-sensitivity effect of soothing substances on sensitive skin
Moreover, the use of in vivo models to measure the antiallergic activity of substances takes a long time and costs more

Method used

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  • Evaluation method for anti-allergen substance for cosmetics
  • Evaluation method for anti-allergen substance for cosmetics
  • Evaluation method for anti-allergen substance for cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] Example 1 A facial mask for detecting sensitive skin

[0114] Preparation of facial mask liquid: The components of the facial mask liquid are shown in the following table. Xanthan gum is first dispersed with 1,3-butanediol and then heated to 80-85°C with water, stirred to dissolve evenly, and kept for 15 minutes. After cooling to 40-45°C, add phase B in sequence, stir for 15-25 minutes, then turn to low speed stirring and cool to 30-35°C before discharging.

[0115] Preparation of the mask: Fill the mask liquid into a mask bag containing a folded mask base material. The mask base material used is a non-woven fabric, the area of ​​the mask base material is 350 square centimeters, and the amount of mask liquid poured is 17.5 g.

[0116] Table 1 Composition of facial mask liquid with phenoxyethanol as a sensitive detection agent

[0117]

Embodiment 2

[0118] Example 2 A facial mask for detecting sensitive skin

[0119] The components of the facial mask liquid are shown in the following table, and the preparation of the facial mask liquid and the facial mask is the same as that described in Example 1. This mask is labeled as Mask A.

[0120] Table 2 Composition of facial mask liquid with phenoxyethanol as a sensitive detection agent

[0121]

[0122]

Embodiment 3

[0123] Example 3 A facial mask for detecting sensitive skin

[0124] The components of the facial mask liquid are shown in the following table. Among them, the mask substrate used is a non-woven fabric, the area of ​​the mask substrate is 300 square centimeters, the pouring amount of the facial mask liquid is 22.5 g, and the rest are the same as those described in Example 1.

[0125] Table 3 Composition of facial mask liquid with phenoxyethanol as a sensitive detection agent

[0126]

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Abstract

The invention discloses a method for evaluating an anti-allergen substance for cosmetics by using a sensitive detecting agent. The method comprises the following steps that 1) a mask used for detecting sensitive skin is prepared, wherein the mask comprises a mask substrate and a mask solution, the mask solution comprises a cosmetic base and the sensitive detecting agent; 2) the anti-allergen substance is added in the mask solution in step 1) to prepare a mask mixed with the anti-allergen substance; 3) the mask prepared in step 1) and the mask prepared in step 2) are applied on the face separately, stimulation is detected, and whether or not the anti-allergen substance has anti-allergen activity is evaluated according to the stimulation response conditions of the skin to the sensitive detecting agent. The evaluation method has the advantages that the operation is simple and convenient, the requirements of operators are lower, experimental results are more objective and true, and the advantages of simple and convenient operation, objective and real experimental results and high sensitivity are achieved.

Description

[0001] This application claims the priority of China's earlier application, application number 201910199966.5, application date 2019-03-15. Technical field [0002] The invention belongs to the technical field of cosmetics, and specifically relates to an evaluation method of soothing substances for cosmetics. Background technique [0003] Sensitive skin refers specifically to a state of high reaction of the skin under physiological or pathological conditions, which mainly occurs on the face. The clinical manifestation is that the skin is prone to burning, tingling, itching and tightness when stimulated by physical, chemical, spiritual and other factors. Subjective symptoms such as sensation, with or without objective signs such as erythema, scales, and telangiectasia. The possible trigger factors for sensitive skin are: (1) Physical factors: such as seasonal changes, temperature changes, and sun exposure; (2) Chemical factors: such as cosmetics, cleaning supplies, disinfection pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61M35/00A61K8/34A61K8/365A61K8/37A61K8/42A61K8/46A61K8/9789A61Q19/00
CPCA61B5/441A61K8/34A61K8/365A61K8/37A61K8/42A61K8/466A61M35/00A61Q19/005A61K8/9789
Inventor 张芝华廖筝筝聂菁
Owner SHANGHAI ZHONGYI DAILY CHEM CO LTD
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