Pharmaceutical use of flavanonol natural products

A drug, the technology of silibinin, which is applied in the field of medicinal use of natural products of dihydroflavonols, can solve the problems such as the elaboration of the therapeutic effect of NASH

Inactive Publication Date: 2019-10-29
CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] At present, there are many studies on the protective effect of silibinin on the liver, but the exact therapeutic effect on NASH has not been elaborated

Method used

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  • Pharmaceutical use of flavanonol natural products
  • Pharmaceutical use of flavanonol natural products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] 1 Grouping of experimental animals

[0021] After single-cage adaptation and gavage adaptation, the animals were divided into 9 groups according to their body weight and food consumption. The mice were adapted for one week, and the mice in groups 2-8 began to be fed with MCD feed. Co-feeding induced 6 weeks, while the normal group Feed mice with normal chow.

[0022] 2 Construction of NASH animal model

[0023] The NASH model induced by a methionine-choline-deficient (MCD) diet was adopted, and MCD is an animal model widely recognized internationally.

[0024] 8-week-old male mice, weighing 18-22g. The body weight of the animals was weighed before the start of MCD modeling. Two weeks after modeling, blood was taken to test serum TG, TC, ALT and AST, and liver was taken to test TG and TC. The NAS pathological score of the model group was greater than 5 points, indicating that the NASH model was successfully constructed. The mice were fed with MCD for 6 weeks.

[00...

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PUM

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Abstract

The invention relates to application of a flavanonol compound, namely silibinin, to treatment of a metabolic disease, namely non-alcoholic steatohepatitis (NASH).

Description

technical field [0001] The invention relates to the use of a dihydroflavonol compound silibinin in treating non-alcoholic steatohepatitis (Non-alcoholic steatohepatitis, NASH), a metabolic disease. Background technique [0002] The present invention relates to the application of silibinin component in treating metabolic disease non-alcoholic steatohepatitis (Non-alcoholic steatohepatitis, NASH). [0003] Silybin {3,5,7-trihydroxy-2-(3-(3-hydroxy-4-methoxy-phenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo [b][1,4]-dioxin-6-yl (dioxin-6-yl)chroman-4-one; or according to the European Pharmacopoeia (Ph.Eur.) called (2R,3R)- 3,5,7-Trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1 , 4-Benzo-dioxin-6-yl]-2,3-dihydro-4H-1-benzopyran-4-one} is the main constituent of silymarin and is derived from milk thistle (Silybum marianum ( The main flavonoid compounds extracted from SilybummarianumGaertneri)). [0004] The structure of silybin is shown below: [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357A61P1/16
CPCA61K31/357A61P1/16
Inventor 姬建新
Owner CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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