Mild low-temperature photothermal anti-tumor material GO-FA-SNX2112

A GO-FA-SNX2112, GO-FA technology is applied in the field of low-temperature photothermal anti-tumor materials to achieve the effect of activating autophagy tumor immunity and promoting tumor immunity

Inactive Publication Date: 2019-11-05
邵增务 +1
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  • Abstract
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  • Claims
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Problems solved by technology

[0004] The technical problem to be solved by the embodiments of the present invention is to propose a mild low-temperature photothermal anti-tumor material GO-FA-SNX2112 in view of the various limitations of current photothermal materials in the clinical field.

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Embodiment Construction

[0034] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0035] The present invention provides a mild low-temperature photothermal anti-tumor material GO-FA-SNX2112. The preparation method of the mild low-temperature photothermal anti-tumor material GO-FA-SNX2112 includes:

[0036] Step 1: Uniformly disperse 20 mg of graphene (GO) in 20 mL of deionized water by ultrasound to prepare a dispersion liquid with a concentration of 1 mg / mL; Step 2: 450 mg of 1-(3-dimethylaminopropyl)-3- Ethylcarbodiimide hydrochloride (ED...

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Abstract

The embodiment of the invention discloses a mild low-temperature photothermal anti-tumor material GO-FA-SNX2112; a preparation method comprises the steps: uniformly dispersing GO in deionized water byultrasound to prepare a dispersed liquid; adding EDC to the dispersed liquid, and stirring; adding NHS and stirring, then mixing NaOH into the solution and adjusting the pH; mixing FA into the obtained solution; after stirring the obtained solution, removing DMSO by a dialysis method; dissolving SNX2112 in DMSO, dispersing to prepare a solution, and then dispersing GO-FA into deionized water to prepare a dispersed solution; mixing a heat shock protein inhibitor solution and the GO-FA dispersed solution evenly and stirring; and carrying out centrifugation washing of the product by PBS for multiple times, removing the free heat shock protein inhibitor, and finally, preparing GO-FA-SNX2112. The mild low-temperature photothermal anti-tumor material GO-FA-SNX2112 can target to a tumor tissue,plays the functions of activating overautophagy and promoting tumor immunity, and then makes tumor cells die.

Description

technical field [0001] The invention relates to an anti-tumor material, in particular to a mild low-temperature photothermal anti-tumor material GO-FA-SNX2112. Background technique [0002] Photothermal therapy has developed rapidly in the treatment of tumors, but because it also has a killing effect on normal tissues during the treatment process, its application in the clinical field is limited, and if it is adjusted to a lower temperature in order to protect normal tissues, the The tumor tissue cannot achieve the desired killing effect. [0003] This material uses the photothermal material graphene to load the heat shock protein inhibitor SNX-2112, which can inhibit the heat shock protein at a relatively low temperature, thereby inhibiting the AKT pathway and activating suicide autophagy, while inhibiting Under the joint action of excessive autophagy and activated tumor immunity, it can kill tumor tissue without affecting normal tissue. However, similar photothermal mate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/22A61K31/416A61P35/00
CPCA61K31/416A61K41/0052A61K47/545A61P35/00A61K2300/00
Inventor 邵增务邓享誉关魏
Owner 邵增务
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