Innovative method for surface modification of biodegradable stent by using laser

A surface modification and laser technology, applied in medical formula, surgery, coating, etc., can solve problems such as unfinished stents and affect the use of stents, achieve structural stability, accelerate the process of endothelialization, and have a wide range of applications

Active Publication Date: 2019-11-05
INNO LASER TECH CORP LTD +1
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Problems solved by technology

However, studies have found that due to the active chemical properties of magnesium, the degradation rate of magnesium alloy stents in the body is too fast, and the mechanical integrity of the stents generally begins to be lost in 5

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  • Innovative method for surface modification of biodegradable stent by using laser

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[0026] In order to make the purpose, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0027] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative efforts fall within the protection scope of the present invention.

[0028] In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Orientation or position indicated by "back", "left", "...

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Abstract

The invention discloses an innovative method for surface modification of a biodegradable stent by using a laser. The innovative method includes the following steps that S1, the surface of a stent material is processed according to a preset contour by using first laser equipment, and a plurality of miniature pits are formed in the surface of the material; S2, the surface of the stent material is processed according to the preset contour with second laser equipment, a highly crosslinked net structure is formed on the surface of the material, and a to-be-processed material is obtained; and S3, the inner surface of the to-be-processed material is coated with attachment proteins, and an artificial substrate layer under endothelial cells is formed, wherein the stent material is a magnesium alloymaterial for manufacturing the biodegradable stent.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to an innovative method for modifying the surface of a degradable stent by using a laser. Background technique [0002] With the gradual improvement of medical level, interventional stent reconstruction of blood supply has become an important means of clinical treatment of cardiovascular and cerebrovascular diseases. At present, stents can be divided into traditional permanent metal stents and new biodegradable stents. Patients using traditional permanent metal stents generally need to take antiplatelet drugs for a long time to prevent the formation of thrombus. However, the stent cannot degrade after completing the supporting function, and long-term stimulation and pulling of the vessel wall will gradually cause in-stent restenosis. Therefore, the researchers proposed a biodegradable stent, which will gradually degrade after providing mechanical support for a period of time a...

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Application Information

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IPC IPC(8): A61L31/02A61L31/10A61L31/14C22F3/00
CPCA61L31/022A61L31/10A61L31/148C22F3/00A61L2400/18C08L89/00
Inventor 赵晓杰吴双王云兵秦国双
Owner INNO LASER TECH CORP LTD
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