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Preparation method of novel oral glucose preparation for oral glucose tolerance test

A technology for glucose tolerance and oral preparations, which can be applied to preparations for in vivo tests, pharmaceutical formulations, compound screening/testing, etc. , Guaranteed accuracy and repeatability, the effect of accurate glucose concentration

Inactive Publication Date: 2019-11-22
杭州市西溪医院
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AI Technical Summary

Problems solved by technology

It can be seen from the data that the missed diagnosis rate in the early asymptomatic stage of diabetes is very high, resulting in patients not being able to receive correct treatment early and timely

Method used

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  • Preparation method of novel oral glucose preparation for oral glucose tolerance test
  • Preparation method of novel oral glucose preparation for oral glucose tolerance test
  • Preparation method of novel oral glucose preparation for oral glucose tolerance test

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] The inventor selects 75g of anhydrous glucose and 300ml of purified water as the basic formula, respectively uses citric acid, malic acid, tartaric acid, maleic acid, fumaric acid, etc. For citric acid, add sodium citrate and lemon essence respectively on the basis of determining the sour agent, use the method of orthogonal test to carry out the experimental design combined with the method of sensory evaluation for evaluation, and finally use the fuzzy relational evaluation set to screen out the oral liquid with the best taste formula.

[0020] 1. Preparation research

[0021] 1. Experimental materials and instruments: purified water, anhydrous glucose, anhydrous citric acid, sodium citrate, DL-malic acid, DL-

[0022] Tartaric acid, fumaric acid, maleic acid, lemon essence, PH902 test pen, analytical balance, etc.

[0023] 2. Experimental content:

[0024] a. Screening of sour agents

[0025] Experimental content: Weigh 150g of anhydrous glucose and dissolve it in ...

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Abstract

The invention relates to a preparation method of an oral glucose preparation. The invention aims to provide a preparation method of a novel oral glucose preparation for the oral glucose tolerance test(OGTT) so as to enhance the accuracy and repeatability of OGTT and improve the taste for patients during the test. According to the technical scheme, the preparation method of the novel oral glucosepreparation for OGTT comprises the following steps: 1) weighing 150g of anhydrous glucose, dissolving the anhydrous glucose in 600ml of purified water, respectively adding citric acid which accounts for 0.15% of the total weight and lemon essence which accounts for 0.05% of the total weight, stirring and dissolving; and 2) filtering with a 0.22-micron microfiltration membrane, bottling, sealing, and sterilizing in a sterilizer.

Description

technical field [0001] The invention relates to a preparation method of oral glucose preparation, which is used for oral glucose tolerance test. Background technique [0002] Oral glucose tolerance test (OGTT) is a glucose load test, which is used to understand the function of pancreatic β-cells and the body's ability to regulate blood sugar. It is a confirmatory test for the diagnosis of diabetes and has been widely used in clinical practice. The OGTT diagnostic standard adopted in my country is the current internationally accepted World Health Organization (WHO) Diabetes Diagnostic Criteria (1999), that is, fasting blood glucose ≥ 7.0mmol / L (126mg / ml), 1h blood glucose ≥ 10.0mmol / L (180mg / ml), 2h blood glucose ≥ 11.1mmol / L (200mg / ml), satisfying any one can be diagnosed as diabetes. [0003] Although OGTT is simple to operate, it has the following problems: [0004] First of all, when oral glucose powder is used for OGTT test, medical institutions may give patients packa...

Claims

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Application Information

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IPC IPC(8): A61K49/00
CPCA61K49/0004
Inventor 蔡兆斌茹仁萍庄辉耀于豫鄂刘寿荣李婷王琦包剑锋李松龙唐红英
Owner 杭州市西溪医院
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