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A fingerprint detection method for antidepressants

A fingerprint and detection method technology, applied in the field of traditional Chinese medicine analysis, can solve problems such as insufficient standardization of extraction and separation of medicinal materials to analysis and detection, large differences in the quality of traditional Chinese medicinal materials, and limitation of fingerprint detection. good stability

Active Publication Date: 2022-05-27
青岛琛蓝健康产业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The fingerprint method has certain limitations for drug detection. For example, the quality of Chinese medicinal materials varies greatly, and different batches and origins also have a greater impact on the detection of fingerprints;
[0005] The detection is greatly affected by the environment and instruments, and the established standards cannot meet the requirements of various time periods or different laboratories; in addition, the standardization of extraction and separation of medicinal materials to analysis and detection is not enough, which also limits the detection of fingerprints.

Method used

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  • A fingerprint detection method for antidepressants
  • A fingerprint detection method for antidepressants
  • A fingerprint detection method for antidepressants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1 of the present invention discloses the determination of the fingerprint of Hypericum perforatum, and the technical scheme adopted is as follows:

[0064] 1. Preparation method

[0065] Hypericum perforatum was added 10 times the amount of 60% ethanol, heated and refluxed for 2 times, 1.5 hours each time, the extracts were combined, concentrated, and dried under reduced pressure; weigh 0.71g, add 50% methanol aqueous solution to a 25ml volumetric flask, and sonicate for 20min Dissolve, add 50% methanol water to volume to the mark, and filter to obtain a sample solution of Hypericum perforatum extract.

[0066] 2. Main instruments

[0067] Chromatography system: Agilent Technologies 1260 Infinity II (G7111B 1260 Quat Pump, G7129A 1260 Vialsampler, G7116A 1260 MCT, G7117B 1290 DAD);

[0068] Ultrasonic cleaning instrument: KQ-600DE, Kunshan Ultrasonic Instrument Co., Ltd.;

[0069] Rotary evaporator: RE-52A, Shanghai Yarong Biochemical Instrument Factory; ...

Embodiment 2

[0094] Embodiment 2 of the present invention discloses the determination of the fingerprint of Paeonia lactiflora radix extract, and the technical scheme adopted is as follows:

[0095] 1. Preparation method

[0096] Add 10 times the amount of 70% ethanol to Paeonia lactiflora, extract twice by heating under reflux for 1.5 hours each time, combine the extracts, concentrate, dry under reduced pressure, weigh 0.71g, add 50% methanol aqueous solution to a 25ml volumetric flask, and sonicate for 20min Dissolve, add 50% methanol water to volume to the mark, and filter to obtain a sample solution of Paeonia lactiflora paeoniae extract.

[0097] 2. Main instruments

[0098] Chromatography system: Agilent Technologies 1260 Infinity II (G7111B 1260 Quat Pump, G7129A 1260 Vialsampler, G7116A 1260 MCT, G7117B 1290 DAD);

[0099] Ultrasonic cleaning instrument: KQ-600DE, Kunshan Ultrasonic Instrument Co., Ltd.;

[0100] Rotary evaporator: RE-52A, Shanghai Yarong Biochemical Instrument ...

Embodiment 3

[0122] Embodiment 3 of the present invention discloses the determination of the fingerprint of gardenia extract, and the technical scheme adopted is as follows:

[0123] 1. Preparation method

[0124] Add 10 times the amount of 80% ethanol to the gardenia, and extract it twice by heating and refluxing for 1.5 hours each time. Combine the extracts, concentrate, and dry under reduced pressure; weigh 0.71 g, add 50% methanol aqueous solution to a 25 ml volumetric flask, and sonicate for 20 minutes. Dissolve, add 50% methanol water to volume to the mark, and filter to obtain gardenia extract sample solution.

[0125] 2. Main instruments

[0126] Chromatography system: Agilent Technologies 1260 Infinity II (G7111B 1260 Quat Pump, G7129A 1260 Vialsampler, G7116A 1260 MCT, G7117B 1290 DAD);

[0127] Ultrasonic cleaning instrument: KQ-600DE, Kunshan Ultrasonic Instrument Co., Ltd.;

[0128] Rotary evaporator: RE-52A, Shanghai Yarong Biochemical Instrument Factory

[0129] Circulat...

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Abstract

The invention discloses a fingerprint detection method of an antidepressant drug, which uses liquid chromatography to characterize the physical and active components of the antidepressant drug composed of hypericum perforatum, white peony root, gardenia, albizia julibrissin and moutan cortex. An effective detection method is provided to realize the quality control of the traditional Chinese medicine composition. The fingerprint detection method provided by the invention has the advantages of good repeatability and stability.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine analysis, in particular to a fingerprint detection method for antidepressant drugs. Background technique [0002] Fingerprints of traditional Chinese medicines refer to images, graphics, spectrograms and data obtained by using modern information collection technology and quality analysis methods after some traditional Chinese medicines or proprietary Chinese medicines are properly processed, which can show the chemical characteristics of traditional Chinese medicines or proprietary Chinese medicines. kind of map. As a method of quality control, traditional Chinese medicine fingerprints are gradually being valued by people. The most basic attributes of chromatographic fingerprints are integrity and ambiguity. It is a comprehensive and quantifiable identification method. On the basis of systematic research on the chemical composition of traditional Chinese medicine, it is mainly used to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06G01N30/74G01N30/86
CPCG01N30/06G01N30/74G01N30/8686
Inventor 宗建成邹圣灿李文玉解植彩张曾亮王尚龙
Owner 青岛琛蓝健康产业集团有限公司
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