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Application of polygonatum sibiricum in regulation of intestinal microorganisms

A technology for regulating the intestines and microorganisms, applied in the field of medicine and health care, can solve the problem of not exploring the pharmacological effects of intestinal flora imbalance

Pending Publication Date: 2019-12-03
ZHUHAI QLWEL BIO TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent document CN105343515A discloses a traditional Chinese medicine composition that has a good therapeutic effect on intestinal flora imbalance and enteritis caused by plateau hypoxic environment. The inventor did not explore the pharmacological effects of the traditional Chinese medicine composition in treating intestinal flora imbalance

Method used

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  • Application of polygonatum sibiricum in regulation of intestinal microorganisms
  • Application of polygonatum sibiricum in regulation of intestinal microorganisms
  • Application of polygonatum sibiricum in regulation of intestinal microorganisms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] The preparation of embodiment 1 Polygonatum chinensis powder

[0065] Pour the harvested Rhizoma Polygonatum rhizomes into cold water, wash the soil clean, slice, and dry the Polygonatum chinensis slices in a drying box at a drying temperature of 80 °C and a drying time of 3 hours. Input it into a pulverizer for pulverization, pulverize it to 900 mesh, and sterilize the pulverized Polygonatum chinensis powder into powder and then vacuum-pack it.

Embodiment 2

[0066] Example 2 Preparation of Polygonatum chinensis extract by ethanol extraction

[0067] The raw material slices of Polygonatum rhizomes are dried, the baking temperature is 80 ° C, and pulverized to 20 meshes to obtain Polygonatum chinensis coarse powder, which is extracted 3 times with 80% ethanol solution, and the extract is filtered and concentrated under reduced pressure to obtain Polygonatum chinensis concentrate. Polygonatum concentrate was eluted through an adsorption column, and the adsorption column was filled with HPD100. First, it was washed with purified water to remove impurities, and then eluted with 60%, 70%, and 80% ethanol to obtain the eluent, and the eluent was concentrated under reduced pressure. Decolorization treatment, purification, concentrated under reduced pressure to extract, freeze-dried to obtain Polygonatum chinensis extract.

Embodiment 3

[0068]Embodiment 3 water decocting method prepares Polygonatum extract

[0069] Select Polygonatum rhizome with high medicinal value for extraction, weigh 100g of medicinal material, put it in a fryer with a suitable volume, add about 600ml of water to immerse the medicinal material for 1 hour, boil and heat for 0.5 hour. Separate the decoction, decoct the dregs for the second time, mix the decoction with the first decoction, measure the volume with a measuring cylinder, if the volume exceeds 600ml, further boil the decoction and concentrate it to about 600ml to reach the corresponding volume Finally, the decoction liquid is vacuum-packed, packed into 7-8 small bags, and stored at 4°C for later use.

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Abstract

The invention provides application of polygonatum sibiricum in regulation of intestinal microorganisms and application of the polygonatum sibiricum in preparation of a drug. The drug is a drug for treating diseases related to intestinal flora disorder.

Description

technical field [0001] The invention belongs to the field of medicine and health care, and in particular relates to the use of Polygonatum chinensis in improving and regulating intestinal microorganisms. Background technique [0002] A large number of microorganisms coexist in the human body. In particular, there are 1000-1150 species of about 100 trillion bacteria in the human intestine, which is the most important "endogenous environmental factor" of the human body, and its number is about 10 times that of the human body's own cells. Under normal circumstances, gut microbes are in a dynamic and balanced ecological environment. The normal flora not only plays an irreplaceable role in digestion, immunity and anti-virus, but also changes in gut microbes are closely related to body health or diseases, especially some chronic diseases. The occurrence of disease is closely related. In the contemporary social environment, people work intensively, live under high pressure, and th...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K45/06A61P1/12A61P1/10A61P3/04A61P37/08A61P1/18A61P1/16A61P1/00A61P29/00A61P1/04A61P13/04A61P3/10A61P15/00A61P19/02A61P9/00A61P9/10A61P35/00A61P25/02A61P25/00A61P19/08A61P25/24A61P39/00A61P25/22A61P25/16A61P37/02
CPCA61K36/232A61K36/481A61K36/8969A61K45/06A61P1/00A61P1/04A61P1/10A61P1/12A61P1/16A61P1/18A61P3/04A61P3/10A61P9/00A61P9/10A61P13/04A61P15/00A61P19/02A61P19/08A61P25/00A61P25/02A61P25/16A61P25/22A61P25/24A61P29/00A61P35/00A61P37/02A61P37/08A61P39/00A61K2300/00Y02A50/30
Inventor 魏来梁桥星葛小菲
Owner ZHUHAI QLWEL BIO TECH LTD
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