Method and system for extracting immunotherapy neoantigen

An immunotherapy and antigen technology, which is applied in the direction of cancer antigen components, tumor-specific antigens, chemical instruments and methods, etc., and can solve problems such as limitations and a small number of neoantigens

Active Publication Date: 2019-12-03
NEOCURA BIO-MEDICAL TECH CO LTD
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, for malignant tumors with a small tumor mutation load, the selection of tumor neoantigen vaccine formulations may be limited due to the small number of predicted neoantigens

Method used

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  • Method and system for extracting immunotherapy neoantigen
  • Method and system for extracting immunotherapy neoantigen
  • Method and system for extracting immunotherapy neoantigen

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Embodiment Construction

[0062] The preferred embodiments of the present invention will be described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0063] The embodiment of the present invention provides a schematic diagram of a method for extracting neoantigens for immunotherapy. Such as figure 1 shown, including:

[0064] Step S1: Obtain the routine proteome of the sample tumor tissue and the sample normal tissue;

[0065] Step S2: obtaining the base monomer unit sequence library of the sample tumor tissue and the sample normal tissue and the specific proteome of the sample tumor tissue;

[0066] Step S3: Obtain several candidate tumor-specific neoantigens based on the conventional proteome of the sample tumor tissue, the specific proteome of the sample tumor tissue, and the HLA molecular typing of the huma...

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Abstract

The invention discloses a method and a system for extracting an immunotherapy neoantigen. The method comprises the following steps: S1, acquiring conventional proteomes of a tumor tissue and a normaltissue of a sample; S2, obtaining a base monomer unit sequence library of a sample tumor tissue and a sample normal tissue and a specific proteome of the sample tumor tissue; S3, based on the conventional proteome of the sample tumor tissue, the specific proteome of the sample tumor tissue and human leukocyte antigen (HLA) molecular typing, obtaining a plurality of candidate tumor specific neoantigens; S4, based on the plurality of obtained candidate tumor specific neoantigens, respectively calculating the existence conditions in a sample tumor tissue conventional proteome, a sample normal tissue conventional proteome, a sample tumor tissue basic group monomer unit sequence library and a sample normal tissue basic group monomer unit sequence library, and taking the existence conditions andgene expression change multiples as filtering rules to obtain the tumor specific neoantigen. From the aspect of source, the tumor specific neoantigen part discovered by the scheme of the invention comes from a genome non-coding region and is not limited to a coding region, so that more neoantigens can be discovered.

Description

technical field [0001] The invention relates to the technical field of tumor immunotherapy, in particular to a method and system for extracting neoantigens for immunotherapy. Background technique [0002] At present, malignant tumor is one of the most serious diseases to human beings. The treatment methods for malignant tumors have been continuously enriched and developed in the past few decades. The current conventional treatment methods for malignant tumors include surgery, radiotherapy, chemotherapy and targeted therapy. However, the above treatment methods have certain limitations and are easily affected by toxic side effects and tumor recurrence. [0003] In recent years, immunotherapy based on activating the immune system to suppress and kill tumor cells has become a new hot spot in the field of malignant tumors. The main immunotherapies can be divided into three categories according to their mechanism of action: [0004] (1). Immune checkpoint inhibitors that activ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B30/00G16B25/00C12Q1/6886
CPCG16B30/00G16B25/00C12Q1/6886A61K39/0011C07K14/4748C40B40/06C40B40/10C12N15/1072A61K2039/70G16B20/10
Inventor 万季宋麒潘有东夏迪刘鹏汪健
Owner NEOCURA BIO-MEDICAL TECH CO LTD
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