Preparation method and medical new purpose of stem and leaf total flavonoids of glycyrrhiza uralensis Fisch. or glycyrrhiza glabra L. or glycyrrhiza inflata Bat.

A technology of total flavonoids, stems and leaves, applied in the field of medicine, can solve the problems of not finding the total flavonoids of licorice stems and leaves, not finding the application of medicines and health care products for hyperlipidemia and obesity, etc.

Inactive Publication Date: 2019-12-13
赵全成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Before the completion of the present invention, it has not been found that the total flavonoids of licorice stems and leaves have the effect of inhibiting lipase, nor has it been found that the total flavonoids of licorice stems and leaves of the present invention can be used in medicines and health products for preventing and treating hyperlipidemia and obesity

Method used

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  • Preparation method and medical new purpose of stem and leaf total flavonoids of glycyrrhiza uralensis Fisch. or glycyrrhiza glabra L. or glycyrrhiza inflata Bat.
  • Preparation method and medical new purpose of stem and leaf total flavonoids of glycyrrhiza uralensis Fisch. or glycyrrhiza glabra L. or glycyrrhiza inflata Bat.
  • Preparation method and medical new purpose of stem and leaf total flavonoids of glycyrrhiza uralensis Fisch. or glycyrrhiza glabra L. or glycyrrhiza inflata Bat.

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Effect test

Embodiment 1

[0044] The preparation of embodiment 1 total flavonoids of licorice stem and leaf

[0045] Extract 50 kg of slices of licorice stems and leaves with 10 times the amount of hot water at 55°C twice for 6 hours, filter, and discard the filtrate; extract the stems and leaves of licorice after reflux with 85% ethanol for 2 time, the extraction time is 2 hours, filter, combine the filtrate, add medicinal activated carbon with a volume of 1.0% of the liquid medicine, stir, filter, collect the filtrate, pass the filtrate through a pre-treated AB-8 macroporous resin column, collect through The ethanol solution of the macroporous resin, the ethanol was recovered under reduced pressure, and dried to obtain 1622 g of total flavonoids in licorice stems and leaves, with a total flavonoid content of 88.1%.

Embodiment 2

[0046] The preparation of embodiment 2 capsules

[0047] Take 200 g of total flavonoids from stems and leaves of licorice, add appropriate amount of starch 100 g, granulate with 75% ethanol, dry, pack into capsules, and make 1000 capsules.

Embodiment 3

[0048] The preparation of embodiment 3 tablet

[0049] Take 200 g of total flavonoids from stems and leaves of licorice, add appropriate amount of starch 100 g, granulate with 75% ethanol, dry, and compress into tablets to make 1000 tablets.

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Abstract

The invention relates to a preparation method and new purpose of glycyrrhiza uralensis Fisch. (Glycyrrhiza uralensis Fisch.) or glycyrrhiza glabra L.(Glycyrrhiza glabra L.) or glycyrrhiza inflata Bat.(Glycyrrhiza inflata Bat.) stem and leaf total flavonoids. Specifically, for the first time, the inventor of the invention finds that the stem and leaf total flavonoids of the glycyrrhiza uralensis Fisch. or the glycyrrhiza glabra L. or the glycyrrhiza inflata Bat. have good effect of restraining lipases, and have favorable preventing and treating effects on hyperlipaemia and obesity. The stem and leaf total flavonoids of the glycyrrhiza uralensis Fisch. or the glycyrrhiza glabra L. or the glycyrrhiza inflata Bat. can be used for preparing medicines and health-care foods for preventing and treating the hyperlipaemia and the obesity.

Description

technical field [0001] The invention discloses that the total flavonoids of licorice stems and leaves have the function of inhibiting lipase and its application in the prevention and treatment of hyperlipidemia and obesity. It also relates to the extraction and separation of total flavonoids and pharmaceutical preparations. The invention belongs to the field of medical technology. Background technique [0002] The fat in the food is hydrolyzed by lipase into monoacylglycerol and free fatty acid, which is absorbed in the intestine, and then the fat is re-synthesized in the body, resulting in fat accumulation and eventually obesity. And hyperlipidemia is also directly related to lipase. Lipase inhibitors can prevent and treat hyperlipidemia and obesity by inhibiting lipase activity and reducing fat entering the body, and help prevent and reduce a series of diseases such as cardiovascular disease and diabetes caused by obesity. [0003] Although orlistat, a semi-synthetic panc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61P3/06A61P3/04A23L33/105A61K127/00A61K135/00
CPCA23V2002/00A61K36/484A61K2236/331A61K2236/333A61K2236/39A61K2236/55A23L33/105A61P3/04A61P3/06A23V2200/332A23V2200/3262A23V2250/2116A23V2300/14A23V2300/02
Inventor 王莲萍何忠梅南敏伦赫玉芳赵昱玮赵全成
Owner 赵全成
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