An interactive parametric simulation method of 3D DNA conformation for middle school teaching

Abstract

The invention relates to an interactive parameterized three-dimensional DNA conformation simulation method for middle school teaching, which uses a double-linked list as the underlying data structure to generate DNA base sequence fragment single strand 1# and another single strand that matches it but contains errors 2#, interactively correct the polarity direction and base complementary pairing errors of single strand 2#, and simulate the primary structure of DNA; on this basis, interactively select the type of DNA, and calculate the local reference frame of the double helix secondary structure, Simulate the dynamic process of DNA base pair stacking and helix according to the frame, and display each secondary structure parameter on the 3D model; update the local reference frame by interactively editing the space curve, so that the linear DNA double strands bend and wind in space , to simulate various supercoiled high-level structures of DNA from linear to curved to arbitrary coiled and wound. The invention can interactively simulate and display the DNA conformation, which helps to accelerate and deepen students' understanding and understanding of the DNA conformation.

Description

technical field [0001] The invention relates to the fields of computer simulation and education, in particular to an interactive parametric simulation method of three-dimensional DNA conformation for middle school teaching. Background technique [0002] The spatial structure of DNA molecules is an important content of high school biology courses. A single deoxynucleotide chain cannot exist stably. So what kind of structure does a DNA molecule composed of such long chains need to have in order to exist stably and be passed on to future generations? In addition, how biomacromolecules achieve highly specific interactions between biomolecules through the specific spatial arrangement (also called conformation) of the constituent atoms of DNA molecules, which is of great significance for understanding the structure and function of biomolecules in inquiry learning. [0003] In-depth understanding and understanding of the spatial arrangement of the constituent atoms of DNA molecules...

AI Technical Summary

Problems solved by technology

However, limited by technology, 3D genome research is still in the descriptive stage, and it is impossible to give a comprehensive explanation of how the geometric structure of DNA determines biological functions.

[0006] Existing studies on the geometric structure of DNA space need to calculate the change of energy to determine the different conformations of the geometric structure of DNA space, focusing on complex numerical calculations, which are poor intuition and operability

In the existing technology, OpenGL is used for simulation, but the DNA winding model is directly simulated by inputting equations, which leads to low user participation and poor interactivity

In addition, the existing relevant DNA materials used in middle school teaching are mainly schematic diagrams and videos, and the descriptions involving DNA conformation are not only rough but also scarce, not only unable to clearly present the microscopic geometric structure of DNA molecules, but also unable to explain the three-dimensional The relationship between geometric structure and biological function

Images