Pharmaceutical composition for improving fluorouracil sensitivity and application of pharmaceutical composition

A fluorouracil and sensitivity technology, which is applied to the drug combination and the application field of the drug combination, can solve the problems of easy drug resistance and low chemotherapeutic sensitivity, and achieves the effects of improving the therapeutic efficacy and improving the chemosensitivity.
CN110974831APending Publication Date: 2020-04-10SICHUAN PROVINCIAL PEOPLES HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SICHUAN PROVINCIAL PEOPLES HOSPITAL
Publication Date
2020-04-10

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Abstract

The invention discloses a pharmaceutical composition for improving fluorouracil sensitivity. The pharmaceutical composition is characterized in that the pharmaceutical composition comprises fluorouracil and hydroxychloroquine linolenate, wherein the concentration of fluorouracil is 1.25 to 10 [mu] mol / L, and the concentration of hydroxychloroquine linolenate is 10 to 160 [mu] mol / L; a fluorouracilsingle-drug group, a hydroxychloroquine linolenate single-drug group and a fluorouracil combined hydroxychloroquine linolenate group are arranged; each group of experiments is independently repeatedfor three times; tumor cells are added and then are cultured on a micro-culture plate for 24 hours, 48 hours and 72 hours respectively; and data of the tumor cells are observed and recorded. The invention further discloses an application of the pharmaceutical composition for improving fluorouracil sensitivity in colorectal cancer. The pharmaceutical composition has the advantages that fluorouraciland hydroxychloroquine linolenate are combined for use, so that the chemosensitivity of fluorouracil can be improved, and the treatment effect is improved; the medication compliance of colorectal cancer patients can be improved; and meanwhile, the pain of the patients can be relieved.
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Description

technical field

[0001] The present invention relates to the technical field of medicine, in particular to a drug combination for improving fluorouracil sensitivity and the application of the drug combination. Background technique

[0002] Colorectal cancer (CRC) is one of the leading causes of cancer death and is the second most common cancer in women and the third most common cancer in men. In recent years, the incidence of colorectal cancer in China has been increasing. In 2015 alone, 191,000 patients died in China, and its death rate ranks fifth among all cancers. The clinical treatment for CRC is mainly surgical resection of the primary tumor; and when the disease progresses or metastasizes, chemotherapy is used for treatment. Chemotherapy has been the standard treatment for clinical treatment of CRC. According to the National Comprehensive Cancer Network (NCCN) guidelines (2018 edition), the first-line treatment for advanced colorectal cancer is based on 5-fluorouraci...

Claims

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