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Lornoxicam and puerarin eutectic crystal and preparation method thereof

A technology of lornoxicam and puerarin, applied in the field of medicine, can solve the problems of poor water solubility of lornoxicam and puerarin, poor compressibility of lornoxicam, etc., and achieve the effects of increasing solubility and improving compressibility

Active Publication Date: 2020-04-14
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Purpose of the invention: the present invention provides a co-crystal of lornoxicam puerarin and a preparation method thereof, the co-crystal solves the problem of poor water solubility of lornoxicam and puerarin; poor problem

Method used

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  • Lornoxicam and puerarin eutectic crystal and preparation method thereof
  • Lornoxicam and puerarin eutectic crystal and preparation method thereof
  • Lornoxicam and puerarin eutectic crystal and preparation method thereof

Examples

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Effect test

example 1

[0032] The preparation method of lornoxicam puerarin co-crystal:

[0033] Add 0.371g of lornoxicam and 0.434g of puerarin into a mixed solvent of 80mL of methanol and 120mL of chloroform, dissolve it to a clear liquid, evaporate it under reduced pressure at 30°C, dry it in vacuum at 20°C for 24h, and place it in a 155°C resistor The solvent was removed in the furnace for 2 minutes to obtain lornoxicam puerarin eutectic.

example 2

[0035] The preparation method of lornoxicam puerarin sodium salt complex:

[0036] Add 0.371g of lornoxicam and 0.434g of puerarin into a mixed solvent of 40mL of methanol and 160mL of chloroform, dissolve it to a clear liquid, evaporate it under reduced pressure at 55°C, dry it in vacuum at 25°C for 24h, and place it in a 165°C resistor The solvent was removed in the furnace for 2 minutes to obtain lornoxicam puerarin eutectic.

example 3

[0038] The preparation method of lornoxicam puerarin sodium salt complex:

[0039] Add 0.371g of lornoxicam and 0.434g of puerarin into a mixed solvent of 25mL of methanol and 175mL of chloroform, dissolve it to a clear liquid, evaporate it under reduced pressure at 80°C, dry it in vacuum at 35°C for 24h, and place it in a 175°C resistor The solvent was removed in the furnace for 2 minutes to obtain lornoxicam puerarin eutectic.

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Abstract

The invention discloses a lornoxicam and puerarin eutectic crystal, which is formed by combining lornoxicam and puerarin according to a molar ratio of 1: 1, and has a powder X-ray diffraction patternexpressed by a 2theta angle value, and an infrared spectrogram. The method comprises the following steps: dissolving the lornoxicam and the puerarin into an organic solvent according to a certain molar ratio, carrying out reduced pressure rotary evaporation on the solvent, carrying out vacuum drying, and putting into a resistance furnace to remove the solvent, thereby obtaining the lornoxicam andpuerarin eutectic crystal. The eutectic crystal is different from a lornoxicam monomer, a puerarin monomer and a physical mixture of the lornoxicam monomer and the puerarin monomer in powder X-ray diffraction and infrared ray, the crystal form of the eutectic crystal is a new crystal form different from the monomers and the physical mixture, and the compressibility of lornoxicam and the water solubility of the lornoxicam and the puerarin are improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to lornoxicam puerarin co-crystal and a preparation method thereof. Background technique [0002] Lornoxicam (Lornoxicam) belongs to the non-steroidal anti-inflammatory analgesics of the Xicam class. Its action sites are mainly in the central nervous system and peripheral pain areas. It has analgesic, anti-inflammatory and antipyretic effects. It is widely used clinically in rheumatic The treatment of diseases such as arthritis and rheumatoid arthritis occupies an important position in non-steroidal analgesic anti-inflammatory drugs, and has a good market development prospect. Its chemical name is 6-chloro-4-hydroxy-2-methyl-3-(2-pyridinecarbamoyl)-2H-thieno[2,3-e]-1,2-thiazine-1,1 - Dioxide, molecular formula C 13 h 10 ClN 3 o 4 S 2 , the structural formula is as follows: [0003] [0004] Puerarin is an isoflavone compound extracted from the dried roots of Pueraria loba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D513/04C07D407/04
CPCC07B2200/13C07D407/04C07D513/04
Inventor 华韵骆敏倩薛一凡朱恒清程冉高缘张建军
Owner CHINA PHARM UNIV
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