Platycarya strobilacea infructescence extract nanoemulsion and preparation method thereof

A kind of technology of the fruit and extract of the fragrant tree, which is applied in the field of nanoemulsion of the fruit sequence extract of the fragrant tree and its preparation, which can solve the problems of low bioavailability and low water solubility

Inactive Publication Date: 2020-04-24
SHAANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, we also found that, as a commonly used folk drug in the treatment of allergic rhinitis, the extracts of Huaxiangshu infructome, such as gallic acid, caffeic acid and ellagic acid, have low water solubility and low bioavailability, so it is considered to make it nanoemulsion

Method used

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  • Platycarya strobilacea infructescence extract nanoemulsion and preparation method thereof
  • Platycarya strobilacea infructescence extract nanoemulsion and preparation method thereof
  • Platycarya strobilacea infructescence extract nanoemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Weighing according to the proportion of the prescription of the present invention, 6g of the inflorescence extract of the fragrant tree, oxyethylene hydrogenated castor oil: 12.6g, diethylene glycol monoethyl ether: 3.8g, castor oil: 1.9g, water phase: 81g, take Oxyethylene hydrogenated castor oil and diethylene glycol monoethyl ether were mixed by magnetic stirring at 1000r / min for 8 minutes, and stirred evenly. After adding castor oil, continue magnetic stirring at 1000r / min for 15 minutes. After mixing evenly, slowly add the prescribed amount of purified water drop by drop while stirring, and then add the extract of citrus inflorescences, stir at 800r / min for 12h, then centrifuge at 2000r / min for 1h, take the Serum, namely clear and transparent nanoemulsion.

Embodiment 2

[0114] Weighing according to the ratio of the prescription of the present invention; Fragrance tree inflorescence extract: 4g, oxyethylene hydrogenated castor oil: 15g, diethylene glycol monoethyl ether: 4g, castor oil: 3g, water phase: 80g, take oxyethylene Hydrogenated castor oil and diethylene glycol monoethyl ether are mixed by magnetic stirring at 1000r / min, stirring time is 8min, stirring evenly, after adding castor oil, continue magnetic stirring at 1000r / min, stirring time is 15min, mixing evenly Finally, slowly add the prescribed amount of purified water drop by drop while stirring, and then add the extract of the infructome of the fragrant tree, and stir at a speed of 800r / min for 12h, then centrifuge at 2000r / min for 1h, and take the supernatant , to obtain clear and transparent nanoemulsion.

Embodiment 3

[0116] Weighing according to the proportion of the prescription of the present invention; Huaxiangshu infructosis extract: 2g, oxyethylene hydrogenated castor oil: 25g, diethylene glycol monoethyl ether: 2g, castor oil: 1g, water phase: 60g, take oxyethylene Hydrogenated castor oil and diethylene glycol monoethyl ether are mixed by magnetic stirring at 1000r / min, stirring time is 8min, stirring evenly, after adding castor oil, continue magnetic stirring at 1000r / min, stirring time is 15min, mixing evenly Finally, slowly add the prescribed amount of purified water drop by drop while stirring, and then add the extract of the infructome of the fragrant tree, and stir at a speed of 800r / min for 12h, then centrifuge at 2000r / min for 1h, and take the supernatant , to obtain clear and transparent nanoemulsion.

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Abstract

The invention relates to platycarya strobilacea infructescence extract nanoemulsion and a preparation method thereof. The platycarya strobilacea infructescence extract nanoemulsion is prepared from the following components in parts by mass: 2 to 6 parts of a platycarya strobilacea infructescence extract, 5 to 25 parts of an emulsifier, 2 to 6 parts of a co-emulsifier, 1 to 5 parts of an oil phaseand 60 to 100 parts of water. The platycarya strobilacea infructescence extract is prepared into a nanoemulsion. It is shown by stability experiment results that the platycarya strobilacea infructescence extract nanoemulsion is good in mechanical stability, and the prepared nanoemulsion is clear and transparent, and uniform and small in particle size distribution. The platycarya strobilacea infructescence extract nanoemulsion preparation can improve medicine solubility, delay medicine release, and obviously improve the bioavailability and pharmacological activity.

Description

technical field [0001] The invention relates to a nano-emulsion of the infructome extract of the fragrant tree and a preparation method thereof, belonging to the field of new dosage forms of Chinese patent medicines. Background technique [0002] Huaxiangshu infructescence is the infructescence of Juglandaceae Huaxiangshu, also known as Bilixiang, Shaoweixiang, and insecticidal fish. It is produced in the Yellow River Basin and the south, mainly in Shaanxi, South China, and Southwest provinces. The folk application in our country is extensive and has a long history. It has the effects of clearing heat and detoxifying, dispelling wind and relieving pain, promoting blood circulation and removing blood stasis, clearing orifices and draining pus. It is mainly used for nasal sinusitis, headache, internal injury, chest distension, abdominal pain, muscle and bone pain, carbuncle, scabies and other diseases. At present, it is a national traditional Chinese medicine protection. Vari...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61K9/107A61K47/44A61K47/08A61P11/02A61P37/08A61P25/00A61P29/00A61P1/00A61P17/02A61P31/10
CPCA61K9/1075A61K36/52A61K47/08A61K47/44A61P1/00A61P11/02A61P17/02A61P25/00A61P29/00A61P31/10A61P37/08
Inventor 宋逍唐志书胡坤霞孙静汪云兰闫浩常星王晶
Owner SHAANXI UNIV OF CHINESE MEDICINE
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