Preparation method, drug and application of anti-tumor microparticles

A microparticle, anti-tumor technology, applied in the field of anti-tumor, can solve the problems that conventional radiotherapy cannot be applied, and achieve good biological safety and biocompatibility

Inactive Publication Date: 2020-05-01
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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Problems solved by technology

[0003] The invention provides a preparation method, medicament and application of anti-tumor microparticles. The anti-tumor microparticles realize anti-tumor through indirect radiotherapy and solve the technical problem that conventional radiotherapy cannot be applied

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  • Preparation method, drug and application of anti-tumor microparticles
  • Preparation method, drug and application of anti-tumor microparticles
  • Preparation method, drug and application of anti-tumor microparticles

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Embodiment Construction

[0034] The principles and features of the present invention are described below in conjunction with examples, which are only used to explain the present invention and are not intended to limit the scope of the present invention.

[0035] The invention relates to an anti-tumor technology that can replace radiotherapy for indirect radiotherapy, which mainly includes the development of an autologous anti-tumor microparticle, and the anti-tumor microparticle is produced from radiation treatment of tumor cells. The anti-tumor microparticles have broad-spectrum anti-tumor activity, and can effectively kill not only autologous tumor cells but also non-autologous tumor cells. It can inhibit malignant pleural effusion, and also control solid tumors; it can be administered locally or systemically through intravenous administration. Its anti-tumor principle mainly involves the delivery of a large amount of reactive oxygen species and the regulation of the tumor immune microenvironment, s...

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Abstract

The invention provides a preparation method of anti-tumor microparticles. The preparation method includes the following steps: 1) taking in-vitro tumor cells, performing primary tumor cell culture soas to obtain primary tumor cells; 2) irradiating the primary cancer cells and culture solution obtained in the step 1) with X rays, and collecting the supernatant after radiotherapy so as to obtain amixture of the desired microparticles and apoptotic tumor cell fragments; and 3) performing gradient centrifugation on the mixture obtained in the step 2) so as to obtain the anti-tumor microparticles. The invention also provides an anti-tumor microparticle drug, and the drug is obtained through purification and concentration of the anti-tumor microparticles. The anti-tumor microparticles which are prepared by using the preparation method of the anti-tumor microparticles can be applied to preparation of anti-tumor drugs, and the technical problem of no applicability of conventional radiotherapy can be solved.

Description

technical field [0001] The present invention relates to the field of anti-tumor, more particularly, to a preparation method, medicament and application of anti-tumor microparticles. Background technique [0002] Radiation therapy is an effective treatment method for routine clinical treatment of tumors, and tumor radiotherapy is a local treatment method that uses ionizing radiation generated by radiation to treat tumors. About 70% of tumor patients need radiotherapy during treatment, and about 40% of cancers can be cured with radiotherapy. The bystander effect (radiation-induced bystander effect, RIBE) caused by radiation therapy refers to the death of not only the irradiated cells but also the surrounding cells that were not irradiated. The study found that radiation-induced release of microparticles from cells is the main effect product leading to the bystander effect. However, there is no complete preparation method for such microparticles at present, and it is impossib...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/13A61K9/127A61K45/06A61P35/00A61P35/04A61K41/00
CPCA61K9/0019A61K9/127A61K35/13A61K41/0004A61K45/06A61P35/00A61P35/04
Inventor 杨坤禹金红林孙亚洁万超田宇
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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