Preparation method of antitumor microparticles, drug and application

Abstract

The invention provides a preparation method of antitumor microparticles. The preparation method comprises steps as follows: 1), in-vitro tumor cells are obtained and subjected to primary tumor cell culture, and primary tumor cells are obtained; 2), the primary tumor cells obtained in step 1) and a culture solution are subjected to radio therapy irradiation, a supernatant after radio therapy is collected, and a mixture of the required microparticles and apoptotic tumor cell debris is obtained; 3), the mixture obtained in step 2) is centrifuged, and the antitumor microparticles are obtained. Theinvention further provides a drug containing the antitumor microparticles. The drug is prepared from the antitumor microparticles by purification and concentration. The antitumor microparticles prepared with the preparation method of the antitumor microparticles can be used for preparing an antitumor drug. The technical problems of poor effect, heavy side effects and high probability of drug resistance of conventional local chemotherapy can be solved.

Description

technical field [0001] The present invention relates to the field of anti-tumor, more particularly, to a preparation method, medicament and application of anti-tumor microparticles. Background technique [0002] Radiation therapy is an effective treatment method for routine clinical treatment of tumors, and tumor radiotherapy is a local treatment method that uses ionizing radiation generated by radiation to treat tumors. About 70% of tumor patients need radiotherapy during treatment, and about 40% of cancers can be cured with radiotherapy. The role and status of radiotherapy in tumor treatment is becoming more and more prominent, and it has become one of the main means of treating malignant tumors, especially in the treatment of some tumors such as head and neck cancer, breast cancer, lung cancer and cervical cancer. However, some tumors do not routinely receive radiotherapy in clinical practice, such as gastric cancer, colon cancer, bladder cancer, kidney cancer, and malig...

AI Technical Summary

Problems solved by technology

[0004] In order to solve the above problems, the present invention provides a preparation method, medicament and application of anti-tumor microparticles. The anti-tumor microparticles can achieve anti-tumor through indirect radiotherapy, and solve the problem of poor effect of conventional local chemotherapy, large side effects, and easy drug resistance. technical issues

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