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Application of Huangqi Shengmai Decoction in the preparation of pulmonary arterial hypertension medicine

A technology of Huangqi Shengmai decoction and pulmonary arterial hypertension, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of serious side effects and not eliminated, achieve the effect of reducing hypertrophy index, reducing damage, and broad application prospects

Active Publication Date: 2021-09-10
ZHEJIANG XINGUANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these vasodilators did not eliminate the primary pathogenic factors of PAH and completely cured the disease, but only improved symptoms, and their side effects were relatively serious

Method used

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  • Application of Huangqi Shengmai Decoction in the preparation of pulmonary arterial hypertension medicine
  • Application of Huangqi Shengmai Decoction in the preparation of pulmonary arterial hypertension medicine
  • Application of Huangqi Shengmai Decoction in the preparation of pulmonary arterial hypertension medicine

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preparation example Construction

[0028] In the present invention, the preparation method of Huangqi Shengmai Decoction comprises the following steps:

[0029] (1) Mix Codonopsis pilosula, Ophiopogon japonicus, Schisandra chinensis, and Schisandra chinensis, add water 5 to 15 times the weight of the traditional Chinese medicine, and decoct for 1 to 3 hours, and separate the solid and liquid to obtain the decoction and medicinal residues;

[0030] In the present invention, it is preferred to add 10 times the weight of the traditional Chinese medicine to decoct for 2 hours.

[0031] (2) Take the medicinal residues in step (1), add 5 to 15 times the weight of the medicinal residues, decoct for 1 to 3 hours, and separate the solid and liquid to obtain decoction and medicinal residues;

[0032] In the present invention, it is preferred to add water 10 times the weight of the dregs and decoct for 2 hours.

[0033] (3) Combine the decoction obtained in step (1) and step (2), carry out solid-liquid separation, concen...

Embodiment 1

[0045]Take 200g of Codonopsis pilosula, 200g of Ophiopogon japonicus, 50g of schisandra chinensis, and 50g of schisandra chinensis, mix them, add 5000g of water to decoct for 2 hours, and separate the solid and liquid to obtain the decoction and medicinal residues; take the medicinal residues, add 5000g of water to decoct for 2 hours, and separate the solid and liquid to obtain Decoction and medicinal residues; two decoctions are combined, solid-liquid separation is performed again, the filtrate is concentrated, ethanol is added to the concentrated filtrate, alcohol precipitation is carried out, solid-liquid separation obtains a precipitate and a supernatant, and the supernatant is recovered ethanol;

[0046] Add water to the above precipitate and stir evenly, separate the solid from the liquid, take the supernatant, add 2g / 100ml medicinal charcoal to the supernatant to decolorize, separate the solid from the liquid, and obtain a filtrate for future use.

[0047] Take 300g of ...

Embodiment 2

[0051] Take 100g of Codonopsis pilosula, 300g of Ophiopogon japonicus, 30g of schisandra chinensis, and 70g of schisandra chinensis, mix them, add 4000g of water to decoct for 1 hour, and separate the solid and liquid to obtain the decoction and medicinal residues; take the medicinal residues, add 4000g of water to decoct for 1 hour, and separate the solid and liquid to obtain Decoction and medicinal residues; two decoctions are combined, solid-liquid separation is performed again, the filtrate is concentrated, ethanol is added to the concentrated filtrate, alcohol precipitation is carried out, solid-liquid separation obtains a precipitate and a supernatant, and the supernatant is recovered ethanol;

[0052] Mix the above precipitate with water, separate the solid from the liquid, take the supernatant, add 0.5g / 100ml medicinal charcoal to the supernatant to decolorize, separate the solid from the liquid, and obtain a primary filtrate.

[0053] Take 400g of Astragalus membranac...

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Abstract

The invention belongs to the field of new application of medicine, and the invention provides an application of Huangqi Shengmai Decoction in preparing medicine for pulmonary arterial hypertension. The Huangqi Shengmai Decoction provided by the invention can restore the developing hemodynamics of rats with pulmonary hypertension, reduce the hypertrophy index of the right ventricle, and reduce the damage of cardiomyocytes. The compound recipe has remarkable effects on multiple important indicators of pulmonary hypertension treatment, so it can be used to treat pulmonary hypertension and has broad application prospects in the preparation of pulmonary hypertension drugs.

Description

technical field [0001] The invention relates to a new application of medicine, in particular to an application of Huangqi Shengmai Decoction in preparing medicine for pulmonary arterial hypertension. Background technique [0002] Pulmonary artery hypertension (PH / PAH) is a pathophysiological state of abnormally elevated pulmonary arterial blood pressure caused by a variety of known or unknown reasons. In the resting state, the mean pulmonary artery pressure (mPAP) ≥ 25mmHg measured by right heart catheterization is a serious disease. According to the classification of the World Health Organization (WHO) in 2008, pulmonary hypertension can be divided into the following five categories: ①arterial pulmonary hypertension; ②pulmonary hypertension caused by left heart disease; ③pulmonary hypertension caused by lung disease and / or hypoxia ; ④ Chronic thromboembolic pulmonary hypertension; ⑤ Pulmonary hypertension caused by unknown multifactorial mechanism. Pulmonary hypertension ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61P11/00A61P9/12
CPCA61K36/344A61K36/481A61K36/57A61K36/79A61K36/8968A61K2236/331A61K2236/39A61K2236/53A61P9/12A61P11/00A61K2300/00
Inventor 占扎君裘飞君陈艳
Owner ZHEJIANG XINGUANG PHARM CO LTD
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