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Myocardial hypertrophy resistant pharmaceutical composition as well as preparation method and application thereof

A myocardial hypertrophy and composition technology, applied in the field of anti-cardiac hypertrophy pharmaceutical composition and its preparation, can solve the problems of inability to obtain myocardial hypertrophy, limited effect, lack of pertinence, etc., achieve obvious cardiac remodeling protective effect, and the effect is remarkable , reducing the effect of myocardial hypertrophy index

Inactive Publication Date: 2016-02-17
王丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, among these drugs, only angiotensin-converting enzyme inhibitors have achieved a certain clinical therapeutic effect, but the effect is limited, and they cannot achieve very obvious anti-myocardial fibrosis or myocardial hypertrophy effects. There is no obvious evidence for other drugs so far. It can improve myocardial fibrosis or myocardial hypertrophy, so there is currently a lack of targeted and effective therapeutic drugs

Method used

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  • Myocardial hypertrophy resistant pharmaceutical composition as well as preparation method and application thereof
  • Myocardial hypertrophy resistant pharmaceutical composition as well as preparation method and application thereof
  • Myocardial hypertrophy resistant pharmaceutical composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 extract dry cream powder

[0025] (1) Weigh 3.6kg of corn silk, 2.0kg of palm leaf, 0.8kg of cattail and 1.2kg of rose root, combine them, crush them, and extract 3 times with ethanol solution with a volume fraction of 95%. twice the amount of ethanol solution for reflux extraction for 2 hours, and for the second time about 10 times the total amount of medicinal materials for reflux extraction for 1.5 hours, filtered through four layers of gauze, and combined the ethanol extract;

[0026] (2) Weigh 1.2kg Yuanhu, 1.2kg Celosia, 1.5kg Longan Kernel, 0.8kg Coptidis, 0.9kg Agrimony, 0.8kg Rush, 2.5kg Waxy Rice Root and 0.12kg Benzoin, combine, crush, and decoct for 2 For the first time, add purified water about 15 times the total amount of medicinal materials, decoct for 4 hours, add purified water about 13 times the total amount of medicinal materials for the second time, decoct for 3 hours, and combine the decoction;

[0027] (3) Concentra...

Embodiment 2

[0028] Example 2 Pharmacodynamic Research of Chinese Medicine Extract on Anti-myocardial Hypertrophy Mice

[0029]32 Kunming mice, weighing 20-23g, were randomly divided into the following four groups: normal control group, model control group, low-dose extract group and high-dose group, with 8 mice in each group, half male and half male. After the test started, the model control group and each dose group of the extract were continuously injected with isoproterenol subcutaneously on the back. kg, and maintained at this dose for 10 days, free to eat and drink, and inject the same volume of normal saline to the same part of the mice in the normal control group. On the second day of modeling, 120 and 360 mg / (kg·d) Chinese medicine extracts (prepared according to the prescription process in Example 1) were administered to the high-dose and low-dose groups respectively, and the normal control group and the model control group were both Give an equal volume of normal saline to the ...

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Abstract

The invention relates to myocardial hypertrophy resistant pharmaceutical composition as well as a preparation method and an application thereof. The pharmaceutical composition is prepared from traditional herbal medicine raw materials in parts by weight as follows: 30-42 parts of corn stigma, 15-25 parts of Chinese fan palm leaves, 9-15 parts of corydalis roots, 9-15 parts of cockscomb flowers, 11-20 parts of longan seeds, 6-10 parts of coptis roots, 6-12 parts of hairyvein agrimonia herbs, 6-10 parts of cattail pollen, 6-10 parts of common rush, 18-30 parts of glutinosae rice roots, 0.5-2 parts of benzoin and 10-15 parts of multiflora rose roots. The myocardial hypertrophy resistant pharmaceutical composition can remarkably reduce the myocardial hypertrophy index, the diameter and the cross section area of each myocardial cell and the content of myocardial interstitial collagen fibers and has an obvious cardiac remodeling protection function for a patient with myocardial hypertrophy.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to an anti-myocardial hypertrophy pharmaceutical composition and a preparation method and application thereof. Background technique [0002] Cardiac hypertrophy refers to the increase in heart weight and volume in order to adapt to the increase in heart work under the influence of genetics, environment, various physiological and pathological factors, and is mainly characterized by the increase in the volume of cardiomyocytes and the increase in extracellular matrix. Cardiac hypertrophy is regulated by many factors and is a complex dynamic process. Studies have shown that sustained pressure and / or volume overload can increase wall stress and lead to myocardial hypertrophy. Grossly, the weight of the heart increases significantly, and the structure of the ventricle changes; at the cellular level, the length and / or width of the cardiomyocytes increase,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P9/00
Inventor 王丽
Owner 王丽
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