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Application of antihypertensive drug prepared by zidovudine

An antihypertensive and zidovudine technology, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as poor efficacy of antihypertensive drugs, improve arterial stiffness, inhibit cell Effect of hypertrophy and improvement of blood flow

Inactive Publication Date: 2016-06-01
端木鲁健
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the technical defects of the prior art, and provides the application of zidovudine for the preparation of antihypertensive drugs, so as to solve the technical problem of poor curative effect of the antihypertensive drugs of the prior art

Method used

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  • Application of antihypertensive drug prepared by zidovudine
  • Application of antihypertensive drug prepared by zidovudine
  • Application of antihypertensive drug prepared by zidovudine

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Embodiment Construction

[0015] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments.

[0016] Approximate language used in the following examples is for quantitative representations, indicating that certain variations in quantities are permissible without altering essential function. Accordingly, values ​​modified by language such as "about", "approximately" and the like are not limited to the exact value itself. In some embodiments, "about" means that the corrected value is allowed to vary within the range of plus or minus ten percent (10%), for example, "about 100" means any value between 90 and 110. Furthermore, in the expression "about the first value to the second value", both values ​​of the first value and the second value are corrected approximately at the same time. In some cases, the language of approximation may relate...

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Abstract

The invention provides application of an antihypertensive drug prepared by zidovudine. A lot of experiments determine that the zidovudine can improve the pulse wave velocity, improve the arterial stiffness, restrain the vascular smooth muscle cell hypertrophy and reduce the content of collagen fibers in a blood vessel wall, so that the internal diameter of a blood vessel is increased, the blood liquidity is improved, and the infarction volume is reduced. Based on the above active nature, the new application of the antihypertensive drug prepared by the zidovudine is determined; tests discover that the zidovudine can play an exact antihypertensive role in central aortic systolic blood pressure and diastolic blood pressure after oral administration and take effects for a long term after a small dose zidovudine of is taken, the antihypertensive effect of the zidovudine is more gentle, and the sudden drop in blood pressure cannot be caused. Through a rigorous experimental means, the new pharmacological properties of the zidovudine are discovered, and the drug developed by the zidovudine is prominent in curative effect and clear in pharmacological effect and has a prominent promotion prospect.

Description

technical field [0001] The invention relates to the technical field of cardiovascular disease treatment, and further relates to the new medical application of zidovudine, in particular to the application of zidovudine in the preparation of antihypertensive drugs. Background technique [0002] Hypertension refers to the situation where systolic blood pressure ≥ 140mmHg and / or diastolic blood pressure ≥ 90mmHg are measured 3 times on different days without the use of antihypertensive drugs; the patient has a history of hypertension and is currently taking antihypertensive drugs. Although it is lower than 140 / 90mmHg, it is still diagnosed as hypertension. Hypertension is the primary factor leading to cardiovascular and cerebrovascular diseases, and can also cause various complications. For example, the incidence of cerebral hemorrhage, stroke, and coronary heart disease in hypertensive patients is significantly higher than that of other populations; in addition, long-term hype...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7072A61P9/12
CPCA61K31/7072
Inventor 端木鲁健
Owner 端木鲁健
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