3D printing drug release capsules and preparation method and application thereof

A slow-release capsule and 3D printing technology, which is applied in botany equipment and methods, applications, capsule delivery, etc., can solve the problems of affecting drug loading and high difficulty in ink preparation, so as to avoid peak and valley phenomena, reduce the number of medications, and prepare The effect of mild conditions

Active Publication Date: 2020-06-09
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this sustained-release tablet is limited by the printing nozzles during printing, for example, only two gradient releases can be achieved when there are only two printing nozzles
And printing can only be done if the fluidity of the bio-ink containing the drug is adjusted well enough, and it will also affect the drug loading, so the preparation of the ink is also difficult

Method used

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  • 3D printing drug release capsules and preparation method and application thereof
  • 3D printing drug release capsules and preparation method and application thereof
  • 3D printing drug release capsules and preparation method and application thereof

Examples

Experimental program
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Embodiment Construction

[0031] The specific embodiments of the 3D printed drug sustained-release capsules involved in the present invention and its preparation method and application will be described in detail below with reference to the accompanying drawings.

[0032]

[0033] 1. Modeling of 3D printed sustained-release capsules

[0034] Use modeling software (Solidworks or autoCAD, etc.) to build a 3D model of the 3D printed drug sustained-release capsule (hereinafter referred to as "drug sustained-release capsule"), and export it to an STL file format. Import the model into the printing software of the 3D printer and check the correction data.

[0035] One of the design dimensions is illustrated as follows: figure 1 As shown, the bottom diameter of the drug sustained-release capsule is 14mm, the height is 7mm, and the bottom thickness is 1.8mm; the number of chambers is four, and the outer wall thickness of each chamber is designed respectively. The outer wall thickness of the first chamber is...

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Abstract

The invention provides 3D printing drug release capsules and a preparation method and application thereof. Each of the 3D printing drug release capsules is characterized by comprising a base and a capsule body formed in the base, wherein at least two chambers with different outer wall thicknesses are arranged in the capsule body, and each chamber is stuffed with homogeneous medicines or differentmedicines. Because each capsule consists of the base and the chamber capsule body with a gradient wall thickness structure, wherein each chamber structure has different outer wall thicknesses, and each chamber is stuffed with homogeneous medicines or different medicines, so that drug release is controlled step by step along with different dissolving speed of different wall thicknesses of the capsules, the drug release capsules can durably and slowly release medicines within the long time when being taken / implanted in bodies, or placed in required environment as required, peak-to-valley phenomenon is avoided, the drug concentration can be maintained to the effective concentration range for a long time, the availability of drugs is improved, and the number of medication times can be reduced.

Description

technical field [0001] The invention belongs to the technical field of biomaterials and biomanufacturing, and in particular relates to 3D printed drug sustained-release capsules and a preparation method and application thereof. [0002] technical background [0003] In recent years, more and more attention has been paid to sustained-release dosage forms of drugs. Compared with traditional common preparations, sustained-release preparations have significant advantages. This kind of pharmaceutical preparations has the advantages of maintaining a stable and effective drug concentration, prolonging the drug effect, reducing the number of medications, reducing toxic and side effects, and reducing the total dosage of medication. Pay attention to. [0004] Sustained-release drug preparation refers to the slow and non-constant release of drug as required in the prescribed release medium. Sustained-release preparations have the following characteristics: ①Sustained-release propertie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/36A61K47/42B33Y80/00B33Y70/00A01N25/28
CPCA01N25/28A61K9/4816A61K9/4825A61K9/4833B33Y70/00B33Y80/00
Inventor 雷祎凤武明信李静雯黄赫
Owner WUHAN UNIV
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