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Tumor immune cell therapy platform

An immune cell therapy, cell therapy technology, applied in the field of biotechnology, can solve the problems of morbidity and toxicity, incurable metastatic disease, etc.

Pending Publication Date: 2020-06-19
王宝中
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Existing treatments for many cancers (e.g., ovarian cancer), such as chemotherapy and targeted therapy, do not cure metastatic disease and prevent tumor recurrence
In addition, standard-of-care treatments such as chemotherapy can cause significant morbidity and toxicity

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0013] The present invention is further described below:

[0014] This embodiment includes a tumor immune cell therapy platform, a cell therapy platform, characterized in that: the establishment of the cell therapy platform is as follows: 1: The establishment of immune function testing items, wherein the immune function testing items include safety observations Items: physical examination; general conditions: heart rate, heart rhythm, respiration, blood pressure, body temperature; laboratory tests: blood routine, urine routine, stool routine, coagulation function, blood biochemistry, electrocardiogram, other laboratory tests (anti-hepatitis B, chest X-ray , B ultrasound); adverse reaction observation (NCI-CTC 3.0 standard); curative effect observation items: main related symptoms and signs; observation of tumor body changes (imaging); relevant physical and chemical examinations (tumor markers, immune function); Bacteria resident index; body weight change observation; behavior ...

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PUM

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Abstract

The invention discloses a tumor immune cell therapy platform. Tumor immune cell therapy can be standardized through the following steps: one, the establishing of immune function test items; two, the establishing of test specification technologies; three, the training of medical staff and laboratory staff; four, the establishing of a standardized management system; five, the controlling of quality;and six, the establishing of a clinical grade CAR-T cell preparation technology platform; through the building of the platform, tumor treatment can be more standardized, and the probability of errorduring treatment can be reduced; and the monitoring before and after treatment can be performed on the immune cells and cytokines of patients, and therefore, the platform has important clinical significance in preventing CRS.

Description

technical field [0001] The invention relates to the technical field of biotechnology, in particular to a clinical technology platform for tumor immunity based on molecular biology. Background technique [0002] Existing treatments for many cancers (eg, ovarian cancer), such as chemotherapy and targeted therapy, fail to cure metastatic disease and prevent tumor recurrence. Furthermore, standard-of-care treatments such as chemotherapy can cause significant morbidity and toxicity. New therapeutic strategies are needed to treat primary and metastatic ovarian cancer and achieve long-term efficacy. [0003] At present, the morbidity and mortality of malignant tumors are increasing year by year, and it has become a major disease that seriously affects the health of residents. Therefore, effective treatments for malignant tumors are urgently needed. In the body's anti-tumor effect, T cell-mediated cellular immunity plays a vital role. As an immunosuppressive checkpoint molecule, ...

Claims

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Application Information

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IPC IPC(8): A61K35/17A61K35/15A61P35/00A61P35/02
CPCA61K35/15A61K35/17A61P35/00A61P35/02A61K2300/00
Inventor 王宝中王丽萍
Owner 王宝中
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