Preparation and application of enteric preparation for treating cervical spondylosis
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A technology for enteric-coated preparations and cervical spondylosis, applied in the field of preparation of Yuxuebi enteric-coated preparations, which can solve the problems of different Chinese medicine formulas, different extraction rates, and complex components
Active Publication Date: 2020-07-07
LIAONING HUANREN PHARMA
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[0009] However, due to the different formulas and complex components of traditional Chinese medicine, different extraction methods have different extraction rates for the active ingredients of different medicines, and their usage, dosage, and extraction process conditions have a great impact on the quality of the finished product.
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[0046] 1.2.1 Preparation route of frankincense and myrrh inclusion compound
[0047] 1) Extraction of volatile oil: take frankincense and myrrh for direct steam extraction, extract for 2-6 hours, collect volatile oil and a small amount of steam decoction, and set aside.
[0048] 2) Alcohol extraction: add 60% ethanol to extract 2 times of volatile oil residues, the first 4-6 times 60% ethanol extraction for 1-2h, the second 3-5 times 60% ethanol extraction for 0.5-1h, The filtrates were combined, ethanol was recovered, steam decoction was added, and the concentration was continued to 0.5 times the amount of medicinal materials.
[0049] 3) Preparation of inclusion compound: since 2) the concentrated solution of alcohol extraction has insoluble matter precipitation, the concentrated solution is subjected to nanoemulsion dispersion treatment to obtain nanoemulsion. Then the volatile oil and nanoemulsion are subjected to β-cyclodextrin to obtain.
[0050] 1.2.2 Preparation rout...
Embodiment 1
[0054] (100 prescriptions)
[0055] 2.1 The preparation method of frankincense, myrrh inclusion compound
[0056] 1) Extraction of volatile oil: take 6kg of frankincense and 6kg of myrrh for straight-through steam extraction, extract for 2-6 hours, and collect volatile oil. The extraction time is optimized by the amount of volatile oil, as shown in Table 1.
[0057] Table 1
[0058] Extraction time / h Volatile oil / mL 2 135 3 195 4 245 5 255 6 255
[0059] From the data in Table 1, it can be seen that the amount of volatile oil increases less after 4 hours of straight steam, and basically does not increase after 5 hours. According to the consideration of oil recovery and production cost, it is determined to extract 4 hours.
[0060] 2) Preparation of alcohol extract: The steam decoction in the extraction tank is released for use. Then add 48kg of 60% ethanol, extract at 90°C for 1.5 hours at normal pressure, filter, collect the liquid...
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Abstract
The invention relates to a preparation method of an enteric preparation for treating cervical spondylosis. The method comprises the following steps: by using frankincense and myrrh as raw materials, performing extraction to obtain volatile oil, performing extraction on medicine residues, collecting the filtrate and a steam water decoction, performing concentration, performing dispersion treatmentto prepare a nanoemulsion, and finally performing beta-cyclodextrin inclusion on the nanoemulsion and the volatile oil to obtain a frankincense and myrrh nanoemulsion inclusion compound; and by usingrhizoma cyperi, rhizoma curcumae longae, rhizoma ligustici chuanxiong, radix clematidis, danshen root, radix cyathulae, radix angelicae sinensis, and honey-fried radix astragali as raw materials, adding water, performing heating reflux extraction, adding safflower during extraction, collecting the filtrate, performing concentration, and performing filtration to remove macromolecular impurities toobtain the enteric preparation. The enteric preparation overcomes the defect that a preparation prepared from medicines such as frankincense and myrrh for promoting blood circulation and removing blood stasis has irritation to the stomach, and many cervical spondylosis patients with stomach diseases cannot take the preparation for a long time, and the preparation enteric capsules and enteric-coated tablets absorbed through the intestine can effectively reduce gastric irritation, reduce the taken amount, and achieve the effect of improving or treating the cervical spondylosis.
Description
technical field [0001] The invention belongs to the field of preparation of enteric-coated preparations for blood stasis, and particularly relates to a composition for treating cervical spondylosis and a preparation method and application of the enteric-coated preparations. Background technique [0002] The etiology of cervical spondylosis mainly includes internal and external factors: external factors mainly include external invasion of wind-cold dampness pathogens, chronic strain, trauma, etc.; internal factors mainly include qi and blood deficiency, liver and kidney deficiency, qi stagnation and blood stasis, etc. Under the combined action of internal and external pathogenic factors, the operation of the meridians in the neck is blocked, and the circulation of qi and blood is not smooth, which eventually leads to the stagnation of qi and blood in the body, obstruction of the meridians and collaterals, and the lack of nourishment of qi and blood for the muscles and bones. ...
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