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Endogenous metabolic small molecule marker for indicating healthy and aged key pathway and application

A metabolic small molecule, endogenous technology, applied in health index calculation, material separation, material analysis, etc., can solve problems such as complex technical means, inability to industrialize, and lack of technical means to simultaneously evaluate key pathways related to healthy aging

Inactive Publication Date: 2020-07-10
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the current technical means, the technical means to evaluate the changes of each pathway are very complicated, involving a large number of precise experimental means, and it is impossible to carry out industrialization and process operation
Currently, there is no technical means to simultaneously assess one or more key pathways related to healthy aging

Method used

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  • Endogenous metabolic small molecule marker for indicating healthy and aged key pathway and application
  • Endogenous metabolic small molecule marker for indicating healthy and aged key pathway and application
  • Endogenous metabolic small molecule marker for indicating healthy and aged key pathway and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Key pathways for healthy aging based on small molecular markers of endogenous metabolism

[0026] Among them, the World Health Organization defines healthy aging as: in old age, the ability to maintain a series of functional capabilities (including self-satisfaction of one's own needs; ability to learn and make decisions; ability to act, establish and maintain interpersonal relationships, and be able to contribute to society ) And the process of getting a valuable life for oneself (https: / / www.who.int / ageing / healthy-ageing / en / ).

[0027] To achieve healthy aging, the most basic thing is to be able to avoid senile diseases during the aging process (Geriatric Diseases [M]. Science Press, January 1, 2011) and major diseases (implemented from April 3, 2007) As defined in the "Regulations for the Use of Disease Definitions for Critical Illness Insurance"), the elderly will pass the old age with few illnesses and extremely low hospitalization rates.

[0028] The key pathw...

Embodiment 2

[0044] Example 2 Indicate the endogenous small molecule markers of the critical pathway for healthy aging in Example 1

[0045] The present invention also provides a new type of blood diagnostic small molecule markers that indicate the key pathways of healthy aging. This type of markers can be used alone or in combination of two or more to assess the changes in critical pathways of healthy aging, a total of 155 One, including 1-Methyladenosine, 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid (20-Hydroxy-(5Z,8Z,11Z,14Z)- eicosatetraenoic acid), 2-Deoxytetronicacid (2-Deoxytetronicacid), 2-Ethyl-2-Hydroxybutyric acid (2-Ethyl-2-Hydroxybutyric acid), 2-Hydroxy-3-methylbutyric acid (2-Hydroxy -3-methylbutyric acid), 2-Methyl-3-hydroxybutyric acid (2-Methyl-3-hydroxybutyricacid), 2-Oxindole (2-Oxindole), 3,5-Dihydroxybenzoic acid (3,5 -Dihydroxybenzoic acid), 3,6-Anhydro-D-galactose (3,6-Anhydro-D-galactose), 3-Acetyl-11-keto-β-Boswellic acid (3-Acetyl-11-keto-. beta.-boswellic aci...

Embodiment 3

[0069] In Example 3, α-N-Phenylacetyl-L-glutamine (Alpha-N-Phenylacetyl-L-glutamine) was used as a single marker to evaluate the key pathways of healthy aging.

[0070] The specific implementation method is as follows:

[0071] 1. Obtain the subject sample and perform pre-processing: After collecting the subject's blood sample according to a standardized and reasonable operating procedure, add 100 μL of blood to 350 μL of methanol, vortex and mix, centrifuge at high speed, and take the supernatant. Concentrate and dry, add 100μL of acetonitrile to reconstitute, pass through the filter plug, and directly perform liquid chromatography-quadrupole-time-of-flight mass spectrometry (UHPLC-QTOFMS) test.

[0072] 2. Data processing: After UHPLC-QTOFMS test, collect UHPLC-QTOFMS data for analysis. XCMS program is used for data processing, and the parameter setting refers to the software description. After the XCMS program is processed, the charge-to-mass ratio, retention time, peak area and...

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Abstract

The invention discloses an endogenous metabolic small molecular marker for indicating a healthy aging key pathway and application. The number of the endogenous metabolic small molecules is 155. The key pathway is totally 30. The invention provides a new endogenous small molecule marker for indicating the key pathways for blood health and aging for the first time, and the change of the small molecules can be measured to comprehensively evaluate the change of pathways related to health and aging in a human body, thereby providing support for subsequent intervention and response.

Description

Technical field [0001] The invention belongs to the field of biomedicine technology, and specifically relates to an endogenous metabolic small molecular marker indicating a key pathway for healthy aging and its application. Background technique [0002] The aging rate of my country's population is more than twice that of Western countries. Among them, elderly people over 65 will increase from 119 million in 2010 to 360 million in 2050 (accounting for 25.6% of the total population). The intensification of the aging process and the high incidence of senile diseases have seriously affected the quality of life of the Chinese people and increased the burden on families and society. But if the health of the elderly improves by 1% relative to the previous year, the total cost of family care in my country in 2050 will be saved by 2.210 billion yuan. If medical expenses are added, the possible savings of healthy aging will be even more amazing. Taking into account that senile diseases a...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/86G16H50/30
CPCG01N30/02G01N30/8675G16H50/30
Inventor 孔庆鹏李功华杨利琴
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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