Pyrone compound and application thereof
A compound and pyrone technology, applied in the field of pyrone compound structure and its prevention and treatment of Alzheimer's disease, compounds and their medicinal chemistry
Inactive Publication Date: 2020-08-28
OCEAN UNIV OF CHINA
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This type of compound has a brand-new core structure and novel s
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Embodiment 1
[0018] Example 1: Synthesis and biological activity screening of Arisugansin A analogs
[0019] Screening samples: Compound Ia, Compound Ib, Compound Ic, Compound Id
[0020] Screening purpose: Screening of acetylcholinesterase inhibitory activity
[0021] Screening method: modified Ellman method
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The invention provides a pyrone compound and application thereof, and belongs to an acetylcholin esterase inhibitor. An acetylcholin esterase inhibition experiment is carried out on the compound, an experiment result shows that the acetylcholin esterase inhibition effect of the compound Id is obviously superior to that of a positive control drug Tacrine, and the compound Id is expected to be developed into a drug or a prodrug thereof for treating and preventing Alzheimer related diseases.
Description
technical field [0001] The invention relates to a compound and the technical field of medicinal chemistry thereof, in particular to a structure of a pyrone compound and its application in the field of prevention and treatment of Alzheimer's disease. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD) is a neurodegenerative disease clinically manifested by deteriorating cognition and memory function, progressive decline in daily life ability, and accompanied by various neuropsychiatric symptoms and behavioral disturbances. At present, the main obstacle in the research and development of AD drugs is the lack of clinical application indicators of drugs, and the specificity is not strong, and clinical trials often fail due to reasons such as adverse reactions and insufficient efficacy. Even so, there are still 82 AD drugs in the clinical stage, 18 of which have entered the III / IV phase of clinical trials. At present, there are about 40 million Alzheimer'...
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Login to view more IPC IPC(8): C07D491/153C07D493/04A61P25/28
CPCC07D491/153C07D493/04A61P25/28
Inventor 陈平唐宇
Owner OCEAN UNIV OF CHINA
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