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Application of spermidine in preparation of intestinal microecological regulator

A technology of intestinal microecology and regulator, applied in the application field of spermidine in the preparation of intestinal microecological regulator, can solve the problems of intestinal flora imbalance, serious diseases, intestinal microecological imbalance, etc. Improve the effect of intestinal microecological disorders

Pending Publication Date: 2020-09-18
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the body's environmental factors change, such as aging, diet and drugs, it may cause the imbalance of intestinal flora, which will lead to the imbalance of intestinal microecology, and finally induce the occurrence of serious diseases

Method used

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  • Application of spermidine in preparation of intestinal microecological regulator
  • Application of spermidine in preparation of intestinal microecological regulator
  • Application of spermidine in preparation of intestinal microecological regulator

Examples

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Embodiment 1

[0021] 1. Animal handling

[0022] 7-week-old male C57BL / 6 mice were reared under standard experimental conditions: 25±2°C, 50±5% humidity, 12h / 12h light / dark cycle. 40 mice were equally divided into 5 groups (control group, high-fat diet group, low-dose spermidine group, middle-dose spermidine group and high-dose spermidine group). The control group was given normal drinking water and common standard feed (energy is 3.52kcal / g), and the other groups were given high-fat feed (energy was 5.24kcal / g). The middle-dose amine group and the high-dose spermidine group also ingested 5 mg / kg, 10 mg / kg and 20 mg / kg of 25 mg / L spermidine aqueous solution every day in the form of drinking water. 16 weeks of treatment.

[0023] 2. 16S rRNA sequencing analysis

[0024] After 16 weeks of treatment in step 1, the mice were sacrificed, the contents of the cecum of the mice were collected, and the total DNA of the contents of the cecum was extracted to prepare a sequencing sample. The analy...

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Abstract

The invention discloses application of spermidine in preparation of an intestinal microecological regulator, and the bacterial abundance of composition of intestinal flora can be changed by intaking in exogenous spermidine, and particularly intestinal microecological disorder caused by metabolic diseases such as obesity can be improved.

Description

[0001] (1) Technical field [0002] The invention relates to the application of spermidine, a polyamine substance, mainly the application of spermidine in the preparation and development of drugs related to regulating intestinal microecology and functional food. [0003] (2) Background technology [0004] A large number of microorganisms are colonized in the human intestinal tract, forming a relatively stable community and interacting with the human body to form a symbiotic unity, which is called the intestinal micro-ecosystem. Gut microbes can not only regulate intestinal health, but are also closely related to liver, brain, bone, cardiovascular, kidney and other multi-organ and systemic diseases. In view of the fact that gut microbes can significantly affect human health, but the specific mechanism by which gut microbes participate in the occurrence and development of diseases is not completely clear so far. The relationship between metabolites and various diseases is necess...

Claims

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Application Information

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IPC IPC(8): A23L33/00A61K31/132A61P1/00
CPCA23L33/00A61K31/132A61P1/00A23V2002/00A23V2200/32
Inventor 倪银华马灵燕倪利阳傅正伟
Owner ZHEJIANG UNIV OF TECH
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