Multi-parameter tumor blood vessel normalization detection system and detection method

Abstract

The invention discloses a multi-parameter tumor blood vessel normalization detection system and detection method. The system comprises a light source module, an imaging module, a blood flow detectionand analysis module, a blood oxygen detection and analysis module, a blood vessel normalization judgment module and a display module. According to the method, a two-dimensional blood flow image is reconstructed through an algorithm, blood vessel morphology characteristics are extracted through an image processing method, a two-dimensional tumor blood oxygen image is calculated through a laser image and a narrow-band green light image, tumor tissue hypoxia degree information is provided, and through a deep neural network discrimination method and combination with blood flow image characteristics and blood oxygen image characteristics whether tumor vessels are normalized or not can be judged. The method has the advantages of being multi-parameter, non-invasive, non-radiative, intelligent indiagnosis and the like, whether tumor blood vessels are in a normal window period or not is intelligently judged by monitoring tumor blood supply, oxygen supply and blood vessel forms, and a basis isprovided for making a more reasonable anti-tumor combined treatment scheme.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a multi-parameter tumor blood vessel normalization detection system and detection method. Background technique [0002] Cancer is a disease that seriously endangers the physical and mental health of patients, and its morbidity and mortality are high, and the incidence and mortality of cancer in China are increasing year by year. Tumor diseases will not only bring great negative pressure to patients themselves, but also bring heavy economic and spiritual burdens to society and patients' families. At present, the main treatment methods for tumors include surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. Surgical treatment has many contraindications. Chemotherapy and radiotherapy cause severe toxic side effects. Some targeted drug treatments have obvious and quick effects, but tumor cells quickly develop drug resistance. [0003] Tumor blood vesse...

AI Technical Summary

Problems solved by technology

However, the invasiveness of pathological indicators, excessive dependence on accurate sampling, and one-sidedness limit its clinical application.

Existing blood flow imaging technologies, such as MRI, PET, fCT, Doppler ultrasound, etc., due to the limitations of spatial resolution and high requirements for inspection equipment and technology, can only provide blood flow information, but cannot provide information on the inside of the tumor. Oxygen partial pressure, which is of great significance to further clarify the mechanism of tumor combination therapy

In addition, due to the characteristics of the vascular mechanical environment inside the tumor, the vascular parameters of a single tumor tissue cannot accurately reflect the normalization of tumor blood vessels, and guide the reasonable combination of anti-angiogenic drugs and chemotherapy

Images