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Preparation method of tropane alkaloid in anisodus tanguticus

A kind of technology of anisodamine and tropane

Pending Publication Date: 2020-11-03
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, there are few technical reports on extracting scopolane alkaloids from plants. In the experiment of measuring the content of scopolamine and anisodamine in anisodamine, people such as Wang Huan used weakly alkaline reagents ammonia and chloroform to extract. Extraction efficiency is low, and the toxicity of chloroform is stronger, therefore, need to establish a kind of new, efficient, low toxicity extraction method of tropane alkaloids

Method used

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  • Preparation method of tropane alkaloid in anisodus tanguticus
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  • Preparation method of tropane alkaloid in anisodus tanguticus

Examples

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Embodiment 1

[0019] Preparation of tropane alkaloids in embodiment 1, Anisodamine

[0020] Get 500g of Anisodina root, pulverize, add 5000ml containing 4% acetic acid methanol solution, under the condition of power 2500w, ultrasonically extract for 30min, the extract is filtered through a 0.2μm ceramic membrane to remove impurities, and the filtrate is freeze-dried (the freeze-drying condition is cold hydrazine temperature -65°C, drying time is 15 hours) to obtain tropane alkaloids.

Embodiment 2

[0021] Embodiment 2, the preparation of tropane alkaloids in anisodamine

[0022] Get 2kg of Anisodina root, pulverize it, add 30L of 4% acetic acid-methanol solution, under the condition of power 1000w, ultrasonically extract for 20min, the extract is filtered through a 0.1μm ceramic membrane to remove impurities, and the filtrate is freeze-dried (freeze-drying conditions: -55°C, drying time is 25 hours) to obtain tropane alkaloids.

Embodiment 3

[0023] Embodiment 3, the preparation of tropane alkaloids in anisodamine

[0024] Get 4kg of Anisodina root, pulverize, add 60L of 4% acetic acid methanol solution, under the condition of extraction temperature of 65°C, reflux extraction time for 1.5h, the extract is filtered through a 0.1 μm ceramic membrane to remove impurities, and the filtrate is freeze-dried (freeze-dried Conditions (cold hydrazine temperature is -52°C, drying time is 30 hours) to obtain tropane alkaloids.

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Abstract

The invention discloses a preparation method of tropane alkaloids in anisodus tanguticus, which comprises the following steps: preparing and crushing anisodus tanguticus, adding an acetic acid-methanol solution for extraction, filtering the extract by a ceramic membrane to remove impurities, separating the extract by an organic membrane to remove impurities, and drying the extract the water solution penetrating through the organic membrane to obtain the anisodus tanguticus alkaloids. The preparation method is high in extraction efficiency, convenient to operate and beneficial to industrial production, popularization and application.

Description

technical field [0001] The invention specifically relates to a preparation method of tropane alkaloids in anisodamine. Background technique [0002] Anisodora [Anisodus tanguticus (Maxim.) Pascher] is a perennial herbaceous plant of the genus Anisodus in the family Solanaceae. Anisodora is wildly distributed in Qinghai, Tibet, Sichuan, and Gansu, and grows on hillsides and roadsides in alpine areas at an altitude of 2200-4200m. Tibetan medicine often uses the seeds and roots of Anisodamine as medicine. The root of the Tibetan medicine is called "Tangchong Nabao", which has the effects of anesthesia, analgesia, insecticide, sedation, and detoxification. Diseases and insanity. The main active ingredients in anisodamine are scopolane alkaloids, such as atropine, scopolamine, anisodamine, anisodamine, etc. These compounds have the effect of blocking acetylcholine receptors, can expand microvessels, improve microcirculation and anti-shock effects . [0003] At present, there ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D451/10A61K31/46A61P9/00A61P9/02A61P9/04
CPCC07D451/10A61K31/46A61P9/00A61P9/02A61P9/04
Inventor 陈晨周国英吴庆江
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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