Prophylactic or therapeutic agent for hypoxic injury, ischaemia-reperfusion injury and inflammation, cell protection agent for transplantation, and bio-preservation agent

A technology of ischemia-reperfusion and protective agent, which is applied in the prevention or treatment of hypoxia, ischemia-reperfusion disorder or inflammation, and can solve the problems that have not yet been developed and induce fear

Pending Publication Date: 2020-11-10
脑科学香料株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no techniques have been developed to induce fearful emotions or potential intrinsic individual protective effects

Method used

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  • Prophylactic or therapeutic agent for hypoxic injury, ischaemia-reperfusion injury and inflammation, cell protection agent for transplantation, and bio-preservation agent
  • Prophylactic or therapeutic agent for hypoxic injury, ischaemia-reperfusion injury and inflammation, cell protection agent for transplantation, and bio-preservation agent
  • Prophylactic or therapeutic agent for hypoxic injury, ischaemia-reperfusion injury and inflammation, cell protection agent for transplantation, and bio-preservation agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0221] Example 1: Decreased body surface temperature induced by thiazoline related compounds

[0222] experimental method

[0223] The effects of odoric molecules of thiazoline related compounds and the induced natural fear were analyzed. It was anesthetized with pentobital (50 mg / kg, i.p.) Anesthesia with Pentobital (50 mg / kg, i.p.) Anesthesia before the test of C57 / BL6n male mice. On the day of the test, each mouse was placed in a test cage. After 10 minutes, it will be compatible with 271 μmol thiazoline related compounds (2-methyl-2-thiazoline; 2MT) or an odorless molecule (benzene). Methyl ether) infiltrated filter paper in the test cage to expose the change in the body surface temperature on the back by the thermal imager (NEC AVIO). The value of the temperature change of the body surface is calculated as follows: the variation of the difference between the average body surface temperature exposed to water and the average body surface temperature when the exposure to e...

Embodiment 2

[0229] Example 2: Decreased body surface temperature induced by various thiazoline related compounds

[0230] experimental method

[0231] The effect of the peer surface temperature of various thiazoline related compounds was analyzed by the same method as in Example 1. As a control, the effect of odor molecules induced induced induced fear were also analyzed.

[0232] Experimental compounds (in parentheses figure 2 Marking)

[0233] 2-methyl-2-thiazoline (2-methylthiazoline)

[0234] 2,5-dimethyl-2-thiazoline (2,5-dimethylthiazoline)

[0235] 2,2-dimethylthial (2, 2-dimethylthiazolidine)

[0236] 2,4,5-trimethyl-3-thiazoline (TMT)

[0237] Thiazole

[0238] 2-ethyl-2-thiazoline (2-ethylthiazoline)

[0239] Thiomorpholine

[0240] result

[0241] Be figure 2 Middle display.

[0242] figure 2 : Show odor (Anis-FS) exposed to various thiazoline related compounds or induced natural fear + The average change of the body surface temperature. The chart displays the value of mean ± stan...

Embodiment 3

[0244] Example 3: Decomposed frozen behavior induced in various thiazoline related compounds in the abdominal cavity

[0245] experimental method

[0246]The effects of frozen behavior (immortal time) and body surface temperature of mice when administered in abdominal cavity of various thiazoline related compounds. Application of odor molecules 100 μL (about 40 mg / kg, i.p.) Of a solution of 100-fold solutions of physiological saline is carried out by intraperitoneal injection, and the measurement of the body surface temperature is carried out in the same manner as in Example 1. The assay of freezing behavior uses the freeze behavior parsing software (freeze frame2), calculated as a ratio (%) of the fixed time of 20 minutes after administration of the odor molecule. As a control, there is also a change in frozen behavior and a variation of the freezing behavior and the body surface temperature during the intraperitoneal administration and the odor (thiophene) of congenital fear. ...

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PUM

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Abstract

The present invention provides: a prophylactic or therapeutic agent for hypoxic injury, ischaemia-reperfusion injury and inflammation; a cell protection agent for transplantation; and a bio-preservation agent. A prophylactic or therapeutic agent for hypoxic injury, ischaemia-reperfusion injury and inflammation, a cell protection agent for transplantation, and a bio-preservation agent comprising, as an active ingredient, at least one selected from: a heterocyclic compound represented by formula (I) (where the symbols in the formula are as defined in the description) or a salt thereof; an isothiocyanate compound represented by formula (II) S=C=N-R5 (where the symbol in the formula is as defined in the description); and a TRPA1 agonist.

Description

Technical field [0001] The present invention relates to hypoxia barriers, ischemia-reperfusion disorders or prevention or therapeutic agents, transplantation cytotropic, and organism preservatives. Background technique [0002] Human and animals may get the ability to increase survival probability during the end of the crisis during evolution. When the people killed in Snow Mountains are found in a low temperature state, even if the card has been stopped, it is not known as a few cases. In such a case, some stimuli may trigger a potential inherent individual protective effect. Some mammals such as bear and squirrel have hibernation. During hibernation, these animals can maintain life in a state where the body temperature and oxygen consumption is reduced. When the oxygen is stopped due to the cessation of the heart, the cells in high oxygenated organisms such as brain can cause irreversible damage. On the other hand, the recovery of blood flow after the cardiac stops causing the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/425A01N1/02A61K31/167A61K31/26A61K31/341A61K31/352A61K31/381A61K31/40A61K31/426A61K31/428A61K31/44A61K31/4406A61K31/4965A61K31/522A61K31/5375A61K31/54A61K31/5415A61K31/55A61K45/00A61P9/10A61P25/00A61P39/00A61P43/00C07D277/04C07D277/10C07D277/22C07D295/027
CPCA61K31/381A61K31/426A61K31/54A61P9/10A61P39/00A61P41/00A61P31/04A01N1/0226A61K9/0043A61K31/26
Inventor 小早川高小早川令子
Owner 脑科学香料株式会社
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