Method and system for simulating macrophages to improve mouse acute kidney injury experiments

A technology for acute kidney injury and macrophages, applied in the field of experimental teaching, can solve the problems of high cost, time-consuming reproduction, inconvenience in popular science and teaching, etc., to improve experimental skills, improve the sense of substitution, and reduce experimental errors.

Active Publication Date: 2020-11-13
WEST CHINA HOSPITAL SICHUAN UNIV
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Problems solved by technology

[0004] The purpose of the present invention is to provide a method and system for simulating macrophages to improve acute kidney injury experiments in mice, aiming to solve the existing macrophage intervention effect and molecular mechanism on acute kidney injury in mice is complex and requires operators It has high experimental ability, and at the same time, it takes a long time to reproduce the experiment, and it costs a lot of money, which is not convenient for the technical problems of science popularization and teaching

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  • Method and system for simulating macrophages to improve mouse acute kidney injury experiments
  • Method and system for simulating macrophages to improve mouse acute kidney injury experiments
  • Method and system for simulating macrophages to improve mouse acute kidney injury experiments

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Embodiment Construction

[0035] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0036] Please also refer to Figure 1 to Figure 9 Now, a method for simulating macrophages to improve mouse acute kidney injury experiments provided by the present invention will be described. Described a method for simulating macrophages to improve mouse acute kidney injury experiment comprises the following steps:

[0037] S1, select the type of mouse;

[0038] The specific implementation of this step can be:

[0039] S1.1. List several kinds of mice on the selection interface for users to choose;

[0040] S1.2. According to the selection of the user, the inf...

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Abstract

The invention provides a method for simulating macrophages to improve mouse acute kidney injury experiments, and belongs to the field of experiment teaching. The method includes: selecting mouse type;preparation of simulated macrophages; constructing the type of mouse kidney injury model, which comprises an ischemia reperfusion induced acute kidney injury model and an anoxia reoxygenation inducedmouse primary renal tubular epithelial cell oxidative injury model; intervening the selected mouse kidney injury model by using macrophages; acquiring pathological tissue detection data of a mouse sample, and giving experimental summary. The method for simulating macrophages to improve mouse acute kidney injury experiments can assist experimental steps of memory standards, improves experimental skills of users, and is more beneficial to science popularization and teaching of experiments. The invention also provides a system for simulating macrophages to improve mouse acute kidney injury experiments.

Description

technical field [0001] The invention belongs to the field of experimental teaching, and more specifically relates to a method and a system for simulating macrophages to improve mouse acute kidney injury experiments. Background technique [0002] Acute kidney injury is one of the common clinical critical diseases, mainly manifested in the rapid decline of renal function in a short period of time, with high morbidity and mortality, and there is a risk of developing chronic kidney disease and accelerated end-stage renal disease. Although a variety of treatment methods have been verified in animal models of acute kidney injury, there is still no progress in the treatment of acute kidney injury with effective drugs. . [0003] Macrophages are one of the most important immune cells in the body and play an important role in immune defense and inflammation regulation. Macrophages include M2 ​​macrophages. Acute kidney injury in mice includes ischemia-reperfusion-induced acute kidn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G09B23/36
CPCG09B23/36
Inventor 王成世
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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