Application of ester group-containing aromatic propionamide compound and metabolites thereof in preparation of drugs for treating heart failure

A technology of ester-based aramid and metabolites, applied in the field of medicine, can solve the problems of decompensation of myocardial function, decreased left ventricular compliance, inability of myocardial contractility to exert the ejection effect, etc., so as to improve LVSP and improve ejection. The effect of scores

Active Publication Date: 2020-12-01
CHANGCHUN GENESCIENCE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The increase of fibrosis reduces the compliance of the left ventricle, and the myocardial contractility cannot exert its proper ejection effect, thus forming a vicious circle, resulting in decompensation of myocardial function, and finally leading to heart failure

Method used

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  • Application of ester group-containing aromatic propionamide compound and metabolites thereof in preparation of drugs for treating heart failure
  • Application of ester group-containing aromatic propionamide compound and metabolites thereof in preparation of drugs for treating heart failure
  • Application of ester group-containing aromatic propionamide compound and metabolites thereof in preparation of drugs for treating heart failure

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Embodiment Construction

[0027] The present invention discloses the application of an aromatic propionamide compound containing an ester group in the preparation of a drug for treating heart failure. The application of the present invention will be confirmed by specific experiments below. The EG017 mentioned in the article is C 25 h 17 f 3 N 4 o 4 , the preparation method and structural formula of EG017 refer to the content recorded in the patent document whose patent number is CN201410033958.0. In all the figures of the present invention, the order of columns is arranged according to Sham, Model, and EG017 groups from left to right.

[0028] The instrument that experiment of the present invention adopts

[0029] Small animal ventilator, model: V-200046; manufacturer: Harvard Apparatus.

[0030] Vevo small animal ultrasound imaging system, model: 1100, manufacturer: Visualsonics.

[0031] Powerlab 8 / 35 signal acquisition system, model: 8 / 35, manufacturer: ADinstrunents.

[0032] Animal experim...

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Abstract

The invention discloses an application of an ester group-containing aromatic propionamide compound and metabolites thereof in preparation of a drug for treating heart failure. The ester group-containing aromatic propionamide compound is C25H17F3N4O4. The invention has the outstanding effects that the ester group-containing aromatic propionamide compound can improve the ejection fraction, the shortaxis shortening rate and the cardiac output reduction of rats with chronic heart failure, and improve the LVSP of the rats with heart failure. The compound has a positive effect in the application ofpreparing the medicine for treating heart failure.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of an ester group-containing aromatic propionamide compound and its metabolites in the preparation of drugs for treating heart failure. Background technique [0002] Heart failure, referred to as heart failure, refers to the failure of the venous blood to fully discharge the heart due to cardiac systolic and / or diastolic dysfunction, resulting in blood stasis in the venous system and insufficient blood perfusion in the arterial system, resulting in cardiac circulation syndrome. , This kind of disorder symptom group manifests as pulmonary congestion and vena cava congestion. The occurrence of heart failure is generally due to the apoptosis of cardiomyocytes after myocardial infarction, which leads to the progressive loss of effective contractile functional units-myocytes, the compensatory function of surviving cardiomyocytes increases, and the adaptiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4406A61P9/04
CPCA61K31/4406A61P9/04A61K31/455
Inventor 朱新法朱然
Owner CHANGCHUN GENESCIENCE PHARM CO LTD
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