Application of RAB22A gene as target to preparation of myocardial infarction treatment product and related products

A technology of RAB22A, 1. RAB22A, applied in the field of preparation of myocardial infarction treatment products, to achieve the effect of inhibiting ROS up-regulation, reducing inflammatory infiltration, and inhibiting myocardial fibrosis

Active Publication Date: 2021-01-22
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are no relevant reports on the use of RAB22A as a therapeutic target for ventricular remodeling in acute myocardial infarction

Method used

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  • Application of RAB22A gene as target to preparation of myocardial infarction treatment product and related products
  • Application of RAB22A gene as target to preparation of myocardial infarction treatment product and related products
  • Application of RAB22A gene as target to preparation of myocardial infarction treatment product and related products

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0122] 1. Experimental materials and methods

[0123] 1 Experimental materials

[0124] 1.1 Experimental animals

[0125] In this experiment, SPF grade C57BL / 6 male mice, weighing 20-25±3g, were used. The experimental animals were provided by the Shanghai Slack Experimental Animal Center, the license number for the use of experimental animals: SYXK (Fujian) 2014-0001. The RAB22A knockout C57BL / 6 mice were constructed by Saiye Biotechnology Co., Ltd., and were raised and bred with the SPF animal center of our school. Animal experiments were carried out in accordance with the "Guidelines for the Treatment of Experimental Animals" issued by the Ministry of Science and Technology in 2006 and the "Guidelines for the Care and Use of Laboratory Animals" issued by the National Institutes of Health. Placed in the Specific Non-Pathogenic Experimental Animal Center of Fujian University of Traditional Chinese Medicine, raised in an SPF-level laboratory, free to eat and drink, the indoo...

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Abstract

The invention belongs to the field of biopharmaceutical research, and particularly relates to application of a human RAB22A gene as a target to preparation of a myocardial infarction treatment product. It is the first time for the invention to discover that the RAB22A can be applied as a potential target site to preparation of a medicine for treating myocardial infarction. The myocardial infarction can be effectively treated after the expression of the RAB22A gene is inhibited. A nucleic acid molecule or a nucleic acid construct including the nucleic acid molecule provided by the invention canspecifically inhibit and relieve myocardial cell inflammatory infiltration, reduce myocardial cell loss, inhibit myocardial cell apoptosis, inhibit myocardial fibrosis, inhibit reactive oxygen species (ROS) up-regulation,and treat ventricular remodeling after myocardial infarction. A new direction is opened up for myocardial infarction treatment.

Description

technical field [0001] The invention belongs to the field of biomedical research, and specifically relates to the use of the RAB22A gene as a target in the preparation of products for the treatment of myocardial infarction and related products. Background technique [0002] Acute myocardial infarction (AMI) refers to myocardial necrosis caused by acute and persistent ischemia and hypoxia in the coronary arteries. Remission, accompanied by increased serum myocardial enzyme activity and progressive ECG changes, may be complicated by arrhythmia, shock or heart failure with sudden onset, often life-threatening. Acute myocardial infarction is a major public health problem, and its prevention and treatment are urgent and imminent. [0003] Ventricular remodeling (VR) after acute myocardial infarction (AMI) refers to the process of changes in the size, shape and tissue structure of the ventricle, as well as the shape and structure of myocardial cells, which is an important cause o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K48/00A61K31/713A61P9/10C12N15/113C12N15/85A23L33/13
CPCA61K45/00A61K31/713A61P9/10C12N15/113C12N15/85A23L33/13C12N2310/531C12N2310/141C12N2800/107A23V2002/00A23V2200/30
Inventor 彭军沈阿灵褚剑锋沈志清程瑛陈晓萍
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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