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Application of dencichine to preparation of medicament for treating thrombocytopenia

A technology of thrombocytopenia and notoginseng, which is applied in the field of medicine, can solve problems such as no reports, and achieve the effect of significant curative effect and small toxic and side effects

Inactive Publication Date: 2013-09-04
KUNMING SHENGHUO PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, a small amount of notoginseng has been reported as a hemostatic drug in the prior art in China. As introduced in the patent application with publication number CN1292376A, a small amount of notoginseng can achieve hemostatic effect, but notoginseng is used for the treatment of thrombocytopenia , have not been reported

Method used

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  • Application of dencichine to preparation of medicament for treating thrombocytopenia
  • Application of dencichine to preparation of medicament for treating thrombocytopenia
  • Application of dencichine to preparation of medicament for treating thrombocytopenia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Effect of Giving Panax notoginseng on Rat Thrombocytopenia Model Caused by Multiple Injections of Carboplatin

[0025] 1.1 Test material

[0026] Test animals: Wistar rats, male, weighing 180-210 g, purchased from Changchun Yisi Experimental Animal Technology Co., Ltd. Certificate number: SCXK-(Ji) 2011-0004

[0027] Test drugs and configuration methods:

[0028] The test drug notoginseng, specification: 46mk / bottle, provided by Kunming Shenghuo Pharmaceutical Group, batch number: 20120323; freshly prepared with normal saline, stored at 4°C for intraperitoneal injection.

[0029] Recombinant human interleukin-11 for injection, specification: 2.4*10 7AU / 3.0mg, produced by Qilu Pharmaceutical Co., Ltd., batch number: 201202008SK, sterile freeze-dried preparation, stored at 4°C, preparation method: freshly prepared with normal saline, for subcutaneous injection.

[0030] Carboplatin injection, specification: 10ml: 100mg, produced by Qilu Pharmaceutical Co., L...

Embodiment 2 10

[0048] Example 2 Study on the Drug Efficacy of Panax notoginsin in Treating Idiopathic Thrombocytopenic Purpura Model Mice

[0049] 1.1 Experimental materials

[0050] experimental drug

[0051] Notoginseng, specification: 5mg / bottle, provided by Kunming Shenghuo Pharmaceutical (Group) Co., Ltd., batch number: 20091101; prednisone acetate tablets are produced by Tianjin Pacific Pharmaceutical Co., Ltd. (Guoyao Zhunzi H12020809). Grind the prednisone acetate tablet into powder, and make a suspension (0.3g / L) with saline.

[0052] experimental animals

[0053] SPF-grade healthy BALB / C mice, weighing 18-22g, half male and half male; guinea pigs, weighing 250-350g, normal grade, 4-6 weeks old, animals provided by the Experimental Animal Center of Kunming Medical College, animal qualification certificate number : SCXK (Dian) 2005-0008.

[0054] 1.2 Experimental method

[0055] Animal Grouping and Handling

[0056] Healthy BALB / C mice, weighing 18-22 g, were randomly divided i...

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Abstract

The invention relates to an application of a medicament for treating thrombocytopenia and in particular relates to an application of dencichine to preparation of a medicament for treating thrombocytopenia. Dencichine can be prepared into oral preparations or injections by adding pharmaceutically acceptable conventional adjuvants. Pharmacodynamic tests indicate dencichine can be used for effectively inhibiting thrombocytopenia caused by chemotherapy drugs and treating thrombocytopenic purpura, and has obvious curative effects and low toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to the use of a medicine for treating thrombocytopenia, and specifically relates to the application of notoginseng in preparing medicine for treating thrombocytopenia. Background technique [0002] Platelets are the smallest blood cells, and their main functions are coagulation and hemostasis. When the human body is injured and bleeding, platelets will rush to the wound in groups within a few seconds. Then the platelets and other clotting substances in the blood adhere to the wall of the damaged blood vessel and gather together to form a blood clot, which blocks the damaged wound and blood vessel. The number of platelets in healthy people is 100×10 9 / L~300×10 9 / L. Its average life expectancy is 8-12 days. Due to various reasons, the platelet count result is lower than the lower limit of the reference value, which is thrombocytopenia. [0003] Thrombocytopenia can cause the fol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P7/00A61P7/06A61P35/02
CPCY02A50/30
Inventor 蓝桂华兰锋孙晓波
Owner KUNMING SHENGHUO PHARMA GRP
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