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Method and apparatus for pulsatile delivery of nitric oxide

A nitric oxide and algorithm technology, which is applied in the fields of drug devices, nebulizers for treatment, medical science, etc., can solve problems such as toxicity

Pending Publication Date: 2021-03-30
BELLEROPHON THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] While NO can be therapeutically effective when given under the right conditions, it can also become toxic if not given correctly

Method used

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  • Method and apparatus for pulsatile delivery of nitric oxide
  • Method and apparatus for pulsatile delivery of nitric oxide
  • Method and apparatus for pulsatile delivery of nitric oxide

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0082] Example 1: Determining precise breath sensitivity for appropriate trigger / arming thresholds

[0083] In this example (Embodiment 1) a device that detects respiration using a threshold algorithm is used. The threshold algorithm uses pressure to detect breaths; that is, a pressure drop below a certain threshold must be met upon inspiration to detect and count breaths. This pressure threshold can be modified as a result of changing the detection sensitivity of the Example 1 device. Several breath sensitivity settings were tested in this example. Settings from 1 to 10 were tested, with 1 being the least sensitive and 10 being the most sensitive. in cm H 2 The trigger threshold shown by O is the threshold level at which nitric oxide is delivered. Also in cm H 2 The armed threshold shown by O is the threshold level at which the device is armed for the next delivery of nitric oxide. The data are shown in Table 1 below.

[0084] Table 1 below shows the dataset collecte...

example 2

[0088] Example 2: Testing of devices for various breathing patterns

[0089] As noted above, accurate and timely delivery of nitric oxide is critical to the present invention. To ensure the device would deliver precise doses of gas over precise time windows, ten different breathing patterns were tested using mechanical lung and nasal phantoms. Analyzes ten different simulated breathing patterns with varying respiratory rates (8 to 36 bpm), tidal volumes (316 to 912 ml) and inspiratory:expiratory (I / E) ratios (1:1 to 1 :4). These variable breathing patterns are those of subjects expected to be 16 years of age and older, and are summarized in Table 2. Simulate real-world conditions as closely as possible.

[0090] Table 2: Summary of Breathing Patterns Tested

[0091] Respiration rate (bpm) Male Female height (cm) Ideal body weight (kg) Tidal volume (mL) Breathing time (sec) I:E ratio 8 F 174 68.1 456 1.5 1:4 8 M 186 86.4 564 1.5 1...

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Abstract

Described are methods for providing a pulsed dose of nitric oxide during at least the first two-thirds of total inspiratory time in each single breath for a therapeutically relevant period of time.

Description

technical field [0001] The present application relates generally to devices and methods for nitric oxide administration, and more particularly to the pulsatile delivery of nitric oxide to patients in need of therapeutic treatment. [0002] Cross References to Related Applications [0003] This International PCT application claims the benefit of U.S. Provisional Application No. 62 / 672,867, filed May 17, 2018, the entire contents of which are incorporated herein by reference. Background technique [0004] Nitric oxide (NO) is a gas that, when inhaled, serves to dilate blood vessels in the lungs, thereby improving oxygenation of the blood and reducing pulmonary hypertension. Therefore, nitric oxide is provided as an inspiratory breathing phase to provide nitric oxide as a therapeutic gas for patients suffering from disease states (e.g., pulmonary arterial hypertension (PAH), chronic obstructive pulmonary disease (COPD), pulmonary fibrosis with emphysema (CPFE), cystic fibrosi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/087A61B5/091A61M16/00A61M16/06A61M16/20
CPCA61B5/091A61B5/087A61M2202/0275A61M2016/1035A61M16/10A61M16/024A61M2016/0021A61M16/12A61M2202/0208A61M2016/0027A61M16/202A61M16/1005A61M16/0672A61M11/00A61M15/08A61M2205/12A61M2205/50A61M2230/42
Inventor P·沙M·德克尔W·伦纳德D·祖兹维修斯
Owner BELLEROPHON THERAPEUTICS
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