Unlock instant, AI-driven research and patent intelligence for your innovation.

Auratrilactone a, drug for treating anti-Alzheimer's disease, preparation method and application

A technology of acanthus trilactone A, which is applied in the field of medicine, can solve the problem of no activity of trilactone A compound of auranthus aurantium, and achieve the effect of preventing and treating the onset of Alzheimer's disease

Active Publication Date: 2022-02-22
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI +1
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, up to now, there is no report of auratrilactone A compound and its activity in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Auratrilactone a, drug for treating anti-Alzheimer's disease, preparation method and application
  • Auratrilactone a, drug for treating anti-Alzheimer's disease, preparation method and application
  • Auratrilactone a, drug for treating anti-Alzheimer's disease, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0039] The present invention also provides the preparation method of beef tendon trihaldone A shown in the structure of the above scheme, including the following steps:

[0040] 1) Extraction of the beef band with 90% to 95% of the ethanol solution of 90% to 95%, collecting the extract; concentrates the extract, to obtain a dipper, resuspend the dipper in the water, resulting Rough liquid;

[0041] 2) EtOAc EtOAc EtOAc EtOAc EtOAc EtOAc EtOAc Ester extract;

[0042] 3) The ethyl acetate extract is subjected to a small hole resin chromatography, the first gradient elution, the first gradient elution process is: the volume fraction is 30% methanol, the volume fraction is 50%. The methanol aqueous solution, the volume fraction is 70% methanol aqueous solution, the volume fraction is 90% aqueous solution and anhydrous methanol for elution, collecting 5 parts of eluent, sequentially named FR1, FR2, FR3, FR4 and FR5;

[0043] 4) The FR4 performs a positive phase silica gel column chroma...

Embodiment 1

[0081]1) Buffali plant samples from the bullgle fruit small branch 100kg. The bullnut-branch dried pulverized into 80 to 100 mesh after the powder, the volume fraction was 95% ethanol aqueous solution, the extraction temperature was 60 ° C, and the amount of ethanol solution used at each extraction temperature was 100 L, and the heated reflux was extracted three times. Combined extract.

[0082] 2) The obtained extract is concentrated, and the solvent is recovered, the condensation temperature is 4 ° C, the pressure is 0.2 to 0.25 MPa, and the extract is obtained. The concentrated coarse strainer was subjected to 50L water suspension, and the extract was extracted three times in sequence, removing the petroleum ether extraction portion, collecting the residue, extracting the residue using 50 L of ethyl acetate to obtain a ethyl acetate extract .

[0083] 3) After obtaining ethyl acetate extract, the present invention performs a small pore resin (4 L) chromatographic separation, th...

Embodiment 2

[0114] The beef tendon trifle ester A, which is preceded by the method of Example 1, is added to the injection of water, fine filtration, and irrigation sterilization.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle size (mesh)aaaaaaaaaa
Login to View More

Abstract

The invention provides trilactone A, a drug for treating anti-Alzheimer's disease, a preparation method and an application thereof, and belongs to the technical field of medicine; trilactone A of the present invention can affect amyloid precursor protein ( The metabolic pathway of APP) can not only reduce the expression ability of β-amyloid protein Aβ42 and Aβ40, but also promote the conversion of APP to non-Aβ metabolic pathway, showing a certain ability to resist the generation of β-amyloid protein Aβ, and has the ability to prevent and treat Alzheimer's disease pathogenic activity.

Description

Technical field [0001] The present invention relates to the field of drug technology, in particular to beef tendon trifle ester A, a drug and preparation method and application of anti-Alzheimer's disease. Background technique [0002] Bulli-raf harrisonia perforata (BL.) Merr. SIMARUBACEAEABIA, the world is worldwide, and the tropical Africa, tropical Asia and Oceania are distributed. In China, bovine-random is mainly distributed in Fujian, Guangdong and Hainan; common in low altitude shrubs and forests. The beef bungee has the effect of clearing hot fever, with a medication, taste, hardship, and is often used in malaria. However, so far, there have been no reports of cerrical fruit trifle ester A compounds and their activity in the prior art. Inventive content [0003] It is an object of the present invention to provide bovine jaws, a drug and preparation method and application of anti-Alzheimeria, which can affect amyloid precursor protein (APP). Metabolic way, not only reduc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/20A61K31/366A61P25/28
CPCC07D493/20A61P25/28
Inventor 郝小江姚永刚邸迎彤罗荣灿唐小涵
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI