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Application of immune cytokine interleukin-22 in preparation ofanti-depression drug

An immune cell and interleukin technology, applied in the directions of drug combinations, pharmaceutical formulations, peptide/protein components, etc., can solve the problems of side effects, many side effects, and ineffective onset of patients, and achieves small side effects, fast onset, and great application value. Effect

Active Publication Date: 2021-04-16
PEKING UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the mechanism of action of almost all antidepressants mainly involves the transmission of monoamine neurotransmitters. Although the mechanism of efficacy is relatively clear, there are many shortcomings, such as ineffectiveness for some patients and slow onset of action.
In addition, there are relatively many side effects, such as digestive system side effects, metabolic side effects and sexual function side effects, etc.

Method used

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  • Application of immune cytokine interleukin-22 in preparation ofanti-depression drug
  • Application of immune cytokine interleukin-22 in preparation ofanti-depression drug
  • Application of immune cytokine interleukin-22 in preparation ofanti-depression drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0045] As mentioned above, the mechanism of action of almost all antidepressants mainly involves the transmission of monoamine neurotransmitters, relatively many side effects, clear curative effect, but not satisfactory, and some patients are ineffective for almost all antidepressants , the onset time of almost all antidepressants is relatively long, and the inventor has conducted a large amount of research on antidepressants.

[0046] The inventors found that the immune cytokine interleukin 22 (IL-22) has good antidepressant activity, and a certain dosage and concentration of IL-22 is used to treat depression, and the onset of action is fast, the therapeutic effect is definite and significant, and Less side effects. The present invention has been made based on the above findings.

[0047] Therefore, the application of the immunocytokine interleukin-22 involved in the first aspect of the present invention in the preparation of antidepressant drugs.

[0048] Interleukin-22 (I...

Embodiment 1

[0096] Example 1: The role of IL-22 in antidepressant

[0097] Experimental animals: male C57BL / 6J mice (body weight 20-25g).

[0098] 1. After one week of adaptive feeding, the mice were divided into 4 experimental groups for feeding as follows:

[0099] Experimental group 1 (control + vehicle group): the control group was neighbor mice in pairs, separated by partitions, no other treatment was done, and different neighbor mice were replaced every day. This process lasted for 10 days, and the mice were separated on the 10th day. Raise them in separate cages, and inject vehicle (PBS) intraperitoneally at the same time, the injection dose is 100 μL / 25g, a total of 8 mice;

[0100] Experimental group 2 (control + IL-22 0.25μg / 100μL / 25g): the operation was the same as above. On the 10th day, mice were reared in separate cages, and IL-22 was injected intraperitoneally at the same time. The injection dose was 0.25μg / 100μL / 25g, a total of 8 mice;

[0101] Experimental group 3 (CSD...

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Abstract

The invention belongs to the technical field ofanti-depression drugs, and relates to application of immune cell factor interleukin 22 in preparation ofanti-depression drugs. The anti-depression drug containing the immune cell factor interleukin 22 or the composition thereof has the anti-depression characteristic, is quick in onset time, exact and remarkable in treatment effect and small in side effect, and the immune cell factor interleukin 22 has great application value in research and development of the anti-depression drug and treatment of depression.

Description

technical field [0001] The invention belongs to the technical field of antidepressant drugs and relates to the application of immune cytokine interleukin-22 in the preparation of antidepressant drugs. Background technique [0002] Depression, also known as depressive disorder, is characterized by significant and persistent depression as the main clinical feature, and is the main type of mood disorder. Depressed mood is often seen clinically, and emotional depression can range from gloomy to distraught, even pessimistic and world-weary. Severe patients may have suicide attempts or behaviors; some cases have obvious physical anxiety and motor agitation; severe patients may have hallucinations, Delusions and other psychotic symptoms. Each episode of depression lasts at least 2 weeks, or even several years in the elderly. Most cases have a tendency to recur. Most of each episode can be relieved, and some may have residual symptoms or become chronic. [0003] Antidepressant dru...

Claims

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Application Information

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IPC IPC(8): A61K38/20A61K38/18A61P25/24
Inventor 李素霞孙益嵘王菲马燕张咪咪王可陆林时杰
Owner PEKING UNIV
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