Application of short peptide Asp-His-Tyr to preparation of medicine for treating endometriosis

A technology of asp-his-tyr and endometrium, applied in the field of biomedicine, can solve problems such as large side effects, achieve the effect of alleviating abdominal pain and improving endometriosis

Active Publication Date: 2021-04-20
HEILONGJIANG UNIV OF CHINESE MEDICINE
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (2) Danazol is a derivative of androgen in pseudomenopausal th

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of short peptide Asp-His-Tyr to preparation of medicine for treating endometriosis

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0020]Example 1

[0021]Establish an endometriosis animal model

[0022]Among the study of endometriosis, the acquisition of the endometriosis of the endometriosis of the clinic patients, so it is necessary to establish an endometriosis. The inventors selected 45 female mature SPF-stage SD rats, and the endometriosis model was established. It was identified that 32 SD rats were successful, and the success rate was 71%. Specific animal experimental steps (refer to CN102988401A) as follows:

[0023](1) From the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, 45-only mature SPF-level health unmanufactured female SD rats were obtained;

[0024](2) 1% pentobarbital (40 mg / kg) abdominal injection anesthesia;

[0025](3) Take the upper abdomen of rats in routine disinfection, and 1 cm in the shame in combination is 1 cm in a vertical hand of approximately 3 cm;

[0026](4) After entering the abdominal cavity, the uterus is found on the back of the bladder;

[0027](5) Fr...

Example Embodiment

[0039]Example 2

[0040]Treatment of short peptide ASP-HIS-TYR on endometriosis

[0041]Drugs used:

[0042]Pregnant allynone: Pregnant allynone capsules produced by Beijing Zizhu Pharmaceutical Company, dissolved with physiological saline. Short peptide ASP-HIS-TYR: Synthesis and sequencing in Shanghai, the short peptide was diluted with physiological saline to 10 μg / kg.

[0043]Experimental steps:

[0044]32 SD rats in molding were randomly divided into 3 groups (10 of each group, the remaining 2 normal feeding), 10 positive control group (physiological saline gardeing group), positive control group (pregnancy alone) Gecch group, 0.5 mg / kg per day, 10 short peptide ASP-HIS-TYR injection group (10 ml / kg per day). The physiological saline dosage of the control group was the same as the drug volume used by the short peptide ASP-His-Tyr injection group for 4 weeks.

[0045]After 4 weeks, I was again laparotomy. Take the ectopic inner membrane tissue of the corresponding part, placed in the formal...

Example Embodiment

[0055]Example 3 Clinical Test

[0056]1 information

[0057]1.1 general information

[0058]Choose from June 2019 to 80 patients with the first hospital affiliated to Heilongjiang University of Traditional Chinese Medicine, the random digital form is divided into two groups, respectively, for the treatment group and control group, 40 cases of each group, two There were no significant differences in gender, age, and disease before treatment, and the balance between groups was good.

[0059]1.2 diagnostic criteria

[0060]According to the provisions of the 3rd academic conference of the Department of Obstetrics and Gynecology, Chinese Journal of Chinese and Western Medicine, the following diagnostic criteria were prepared in the "Clinical Research Guiding Principles" of Chinese Medicine New Drugs.

[0061]1 gradual dysmenorrhea;

[0062]2 less abdomen, lumbosacral, gradual intensification;

[0063]3 cycle anal pendant;

[0064]4 post-poster, uterus bone ligament or neighborhood contacts;

[0065]5 ovarian chocolat...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to an application of a short peptide Asp-His-Tyr to preparation of a medicine for treating endometriosis. The short peptide Asp-His-Tyr can improve the endometriosis, and is particularly suitable for relieving stomachache and/or abnormal menstruation caused by the endometriosis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of short peptide Asp-His-Tyr in the preparation of medicine for treating endometriosis. Background technique [0002] Endometriosis is a common gynecological disease in women that is caused by active endometrial cells growing outside the endometrium. Endometrial cells should grow in the uterine cavity, but because the uterine cavity communicates with the pelvic cavity through the fallopian tubes, endometrial cells can enter the pelvic cavity through the fallopian tubes for ectopic growth. At present, there are many theories about the pathogenesis of this disease, among which the theory of endometrium implantation is generally accepted. The disease mostly occurs in women of childbearing age. It does not develop before puberty, and the ectopic lesions can gradually shrink and degenerate after menopause. The main pathological changes of endometriosi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K38/06A61P15/00
Inventor 韩亚光朱小琳韩延华韩晗
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap