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Application of polypeptide in preparation of medicine for treating endometriosis

A technology for endometriosis and endometriosis, applied in the field of biomedicine, can solve problems such as large side effects, achieve the effect of relieving abdominal pain and improving endometriosis

Active Publication Date: 2021-12-28
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (2) Pseudomenopausal therapy Danazol is a derivative of androgen, the effect is better, but there are relatively large side effects

Method used

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  • Application of polypeptide in preparation of medicine for treating endometriosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Establishment of an animal model of endometriosis

[0022] In the study of endometriosis, the acquisition of endometriosis tissue from clinical patients is limited, so it is necessary to establish an animal model of endometriosis. The inventors selected 45 female mature SPF SD rats to establish the endometriosis model. It was identified that 30 SD rats were successfully modeled, with a success rate of 67.7%. The specific animal experiment steps (refer to CN102988401A) are as follows:

[0023] (1) 45 sexually mature SPF healthy unmated female SD rats were obtained from the Animal Center of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine;

[0024] (2) Anesthesia by intraperitoneal injection of 1% sodium pentobarbital (40mg / kg);

[0025] (3) After routine disinfection, a longitudinal incision of about 3 cm was made in the middle of the lower abdomen and 1 cm above the pubic symphysis;

[0026] (4) Find the uterus on the back of t...

Embodiment 2

[0040] Test the therapeutic effect of polypeptide on endometriosis

[0041] Medications used:

[0042] Gestrienone: Gestrienone capsules produced by Beijing Zizhu Pharmaceutical Company, dissolved in normal saline. The polypeptide with the amino acid sequence of SEQ ID NO. 1: synthesized and sequenced by Shanghai Shenggong, and the polypeptide was diluted to 10 μg / kg with normal saline.

[0043] Experimental steps:

[0044] The 30 SD rats with successful modeling were randomly divided into 3 groups with 10 rats in each group, namely the negative control group (normal saline gavage group), 10 rats, and the positive control group (gestrinone gavage group, 0.5 per day). mg / kg) 10, and the polypeptide injection group (10ml / kg daily) 10. The dosage of normal saline in the control group was the same as that of the drug in the polypeptide injection group for 4 consecutive weeks.

[0045] After 4 weeks, the laparotomy was performed again, and the ectopic endometrial tissue of the co...

Embodiment 3

[0055] Example 3 Clinical trial

[0056] 1 Information

[0057] 1.1 General information

[0058] Selected 40 patients from the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from October 2019 to December 2019, and divided them into two groups by random number table method, namely the treatment group and the control group, with 20 patients in each group. There were no significant differences in gender, age, and course of disease between the groups before treatment, and the groups were well balanced and comparable.

[0059] 1.2 Diagnostic criteria

[0060] According to the standards stipulated by the third academic meeting of the Obstetrics and Gynecology Professional Committee of the Chinese Association of Integrative Medicine and the "Guidelines for Clinical Research of New Chinese Medicines for the Treatment of EM", the following diagnostic criteria are formulated:

[0061] ① progressive dysmenorrhea;

[0062] ②Short abdomen and lumbo...

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Abstract

The present invention relates to the application of a polypeptide in the preparation of a drug for treating endometriosis. The polypeptide has the amino acid sequence shown in SEQ ID NO.1 or lacks or replaces any one of them compared with the sequence of SEQ ID NO.1 Amino acid or amino acid sequence with one amino acid added. The polypeptide of the present invention can improve endometriosis, and is particularly suitable for alleviating abdominal pain and / or abnormal menstruation caused by endometriosis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of a polypeptide in the preparation of a medicine for treating endometriosis. Background technique [0002] Endometriosis is a common gynecological disease in women caused by the growth of active endometrial cells outside the endometrium. Endometrial cells should grow in the uterine cavity, but because the uterine cavity communicates with the pelvic cavity through the fallopian tube, the endometrial cells can enter the pelvic cavity through the fallopian tube for ectopic growth. At present, there are many theories about the pathogenesis of this disease, among which the theory of endometrial implantation is generally accepted. The disease mostly occurs in women of reproductive age, does not develop before puberty, and ectopic lesions can gradually shrink and degenerate after menopause. The main pathological changes of endometriosis are periodic hem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/08A61K9/08A61K9/19A61P15/00A61P29/00
CPCA61K38/08A61K9/0019A61K9/08A61K9/19A61P15/00A61P29/00
Inventor 朱小琳韩亚光韩延华贾丽研韩亚鹏
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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