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Single-capped organosiloxane macromer, silicone hydrogel, contact lens and preparation method

A technology of organosiloxane and macromolecular monomers, which is applied in glasses/goggles, instruments, optics, etc. It can solve the problems of strong hydrophobicity on the surface of silicone hydrogel, affecting the wearing comfort of lenses, and limited dosage , to achieve the effects of being beneficial to eye health, excellent oxygen permeability and light transmission, and reducing the degree of crosslinking

Active Publication Date: 2022-06-17
JIANGSU HORIEN CONTACT LENS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high hydrophobicity of PDMS, the compatibility with hydrophilic monomers is poor, so the amount of PDMS added is limited, which limits the improvement of the oxygen permeability value of the lens material, and the surface of the obtained silicone hydrogel is relatively strong. , affecting the wearing comfort of the lens

Method used

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  • Single-capped organosiloxane macromer, silicone hydrogel, contact lens and preparation method
  • Single-capped organosiloxane macromer, silicone hydrogel, contact lens and preparation method
  • Single-capped organosiloxane macromer, silicone hydrogel, contact lens and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Preparation of Mono-terminated Organosiloxane Macromers

[0074] Take 14.1g HO-PDMS (number average molecular weight is about 1500, m is about 7, n is about 16, purchased from Nanjing Fuqun Chemical Co., Ltd.), 1.3g glycidyl methacrylate (GMA), 100μL trifluoro Methanesulfonic acid, magnetic stirring, reflux reaction at 30°C for 24h, after the reaction is over, distilled under reduced pressure to obtain an organosiloxane macromonomer, denoted as M1-w1. figure 1 is the infrared spectrum of the single-terminated organosiloxane macromonomer (M1-w1) prepared in Example 1.

[0075]

[0076] where m is about 7 and n is about 16

[0077] (M1-w1)

Embodiment 2

[0079] Preparation of Mono-terminated Organosiloxane Macromers

[0080] Take 54.3g HO-PDMS (number average molecular weight is about 5500, m is about 11, n is about 50, purchased from Nanjing Fuqun Chemical Co., Ltd.), 1.4g glycidyl methacrylate (GMA), 100 μL tetrabutylene ammonium chloride, magnetic stirring, reflux reaction at 50 °C for 5 h, and distillation under reduced pressure to obtain an organosiloxane macromonomer, which is recorded as M1-w2. figure 2 is the infrared spectrum of the single-terminated organosiloxane macromonomer (M1-w2) prepared in Example 2.

[0081]

[0082] where m is about 11 and n is about 50

[0083] (M1-w2)

Embodiment 3-4

[0085] A silicone hydrogel prepared by polymerization of the following components:

[0086]

[0087] Wherein, the single-terminated organosiloxane macromonomer was prepared from Example 1 and Example 2, respectively.

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Abstract

The invention discloses a single-terminated organosiloxane macromonomer, which is excellent in mixing with various hydrophilic monomers under the condition of solvent-free dissolution, and can prepare high oxygen permeability and high hydrophilicity silicone hydrogel material. The present invention also provides a silicone hydrogel, which is prepared by polymerizing the single-end organosiloxane macromonomer and the following components: 5-60 parts of the mono-end organosiloxane macromer , 0-30 parts of small molecular silicon monomer, 10-70 parts of hydrophilic monomer, initiator and crosslinking agent; the silicon hydrogel has good hydrophilic performance, light transmission performance and high oxygen permeability. At the same time, the invention also provides a corneal contact lens made of the silicon hydrogel material, which has the advantages of good oxygen permeability, light transmission, strong hydrophilicity and wearing comfort.

Description

technical field [0001] The invention relates to a single-end-capped organosiloxane macromer, a silicon hydrogel, a corneal contact lens and a preparation method, and belongs to the field of material preparation of contact lens lenses. Background technique [0002] Traditional hydrogel contact lenses are copolymerized with hydrophilic monomers such as hydroxyethyl methacrylate, N-vinylpyrrolidone, etc. There is a general low oxygen permeability, and long-term wearing will cause corneal hypoxia. , resulting in ocular surface problems such as dry eyes, conjunctival hyperemia, and corneal edema. [0003] Silicon hydrogel is a new type of material obtained by introducing silicone structural units into hydrogels. It combines the high oxygen permeability of silicone and the softness of hydrogels, and has higher oxygen permeability than hydrogels. ability, which has been used as one of the materials for contact lenses in recent years. For those who wear contact lenses for a long t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G77/38C08F290/06C08F230/08C08F220/32C08F220/20C08F220/54C08F222/14G02C7/04
CPCC08G77/38C08F290/068G02C7/049C08F230/085C08F220/325C08F220/20C08F220/54C08F222/102
Inventor 张雪勤吴姝陈平韩雪莲王玉东
Owner JIANGSU HORIEN CONTACT LENS
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