Multi-channel biomolecule detection chip based on array nanopores and manufacturing method thereof

A technology of biomolecules and detection chips, which is applied in the direction of material analysis, measurement devices, and analysis materials through electromagnetic means, which can solve the problems of low via efficiency and easy clogging, and achieve the effect of rapid detection and high-throughput screening

Active Publication Date: 2021-07-13
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, the current nanopore detection technology only drives biomolecules through a single nanopore, and there are problems such as easy clogging and low efficiency during the passage process. How to improve the passage efficiency to achieve high-throughput screening of biomolecules is an urgent need to be solved question

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  • Multi-channel biomolecule detection chip based on array nanopores and manufacturing method thereof
  • Multi-channel biomolecule detection chip based on array nanopores and manufacturing method thereof
  • Multi-channel biomolecule detection chip based on array nanopores and manufacturing method thereof

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[0036] The technical solution of the present disclosure will be described in detail below in conjunction with the accompanying drawings. In the description of the present invention, it should be understood that the terms "first" and "second" are only used for descriptive purposes, and cannot be interpreted as indicating or implying relative importance or implicitly indicating the quantity of indicated technical features, Used only to distinguish different components.

[0037] In addition, the terms "top-down", "upper", "lower", "upper surface", "lower surface", "one end", "other end", "display", "bottom", "middle", etc. indicate The orientation or positional relationship is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation or be configured in a specif...

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Abstract

The invention discloses a multi-channel biomolecule detection chip based on array nanopores and a manufacturing method thereof, relates to the technical field of nanopore molecule detection, and solves the technical problem that the existing biomolecule via hole detection efficiency is not high. According to the technical scheme, the method is characterized in that a plurality of nano wires are used for independently detecting and controlling the current change in a single nano hole, so that the opening and closing control of each nano hole can be realized, and biomolecules are blocked or allowed to pass through the holes; meanwhile, simultaneous multi-channel hole passing of the biomolecules can be carried out, and rapid detection and high-throughput screening of the biomolecules are realized.

Description

technical field [0001] The present disclosure relates to the technical field of nanopore molecular detection, in particular to a multi-channel biomolecular detection chip based on array nanopores and a manufacturing method thereof. Background technique [0002] The detection of biomolecules based on nanopore technology originated from the invention of the Coulter counter and the single-channel current recording technology. By adding an electrolyte solution to the liquid pool at both ends, and using electrophoresis technology to drive biomolecules through the nanopore, the biological The change of nanopore current caused by molecules due to space occupation can be used to detect through-pore biomolecules. Therefore, nanopore detection technology is widely used in single-molecule research fields such as DNA detection and protein detection, and is also considered to be a detection technology that can be used for third-generation gene sequencing. However, the current nanopore d...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/327
CPCG01N27/3275G01N27/3278G01N27/26Y02A50/30
Inventor 沙菁刘巍郑斐詹利建
Owner SOUTHEAST UNIV
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